Anticoagulants: A Review of the Pharmacology, Dosing, and Complications.
Anticoagulants: A Review of the Pharmacology, Dosing, and Complications.
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DOI：
10.1007/s40138-013-0014-6
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发表时间：
2013-06
影响因子：
0.7
通讯作者：
Fanikos J
中科院分区：
文献类型：
--
作者：
Alquwaizani M;Buckley L;Adams C;Fanikos J
抗凝剂仍然是预防和治疗血栓形成的主要策略。未分离肝素、低分子量肝素、氟达肝素和华法林已被广泛研究，并与直接凝血酶抑制剂一起广泛应用，通常用于有并发症或需要干预的患者。新型口服抗凝剂已从临床开发中出现，并有望以其易于使用和更有利的药效学特征取代旧的药物。出血是所有抗凝剂的主要不良反应。随着抗凝药物的广泛使用，临床医生对抗凝药物的药理学、剂量和毒性有一个良好的了解变得非常重要。
Anticoagulants remain the primary strategy for the prevention and treatment of thrombosis. Unfractionated heparin, low molecular weight heparin, fondaparinux, and warfarin have been studied and employed extensively with direct thrombin inhibitors typically reserved for patients with complications or those requiring intervention. Novel oral anticoagulants have emerged from clinical development and are expected to replace older agents with their ease of use and more favorable pharmacodynamic profiles. Hemorrhage is the main concerning adverse event with all anticoagulants. With their ubiquitous use, it becomes important for clinicians to have a sound understanding of anticoagulant pharmacology, dosing, and toxicity.