TRANSFORMING GROWTH FACTOR-BETA-3 IS REQUIRED FOR SECONDARY PALATE FUSION
TRANSFORMING GROWTH FACTOR-BETA-3 IS REQUIRED FOR SECONDARY PALATE FUSION
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DOI：
10.1038/ng1295-409
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发表时间：
1995-12-01
期刊：
影响因子：
30.8
通讯作者：
DOETSCHMAN, T
中科院分区：
文献类型：
--
作者：
PROETZEL, G;PAWLOWSKI, SA;DOETSCHMAN, T
缺乏IGF-β 3的小鼠表现出腭架融合的不完全渗透失败，导致腭裂。该缺陷似乎是由于腭架的并置内侧边缘上皮细胞的粘附受损和随后的中线上皮接缝的消除造成的。未观察到颅面异常。这一结果表明，TGF-β 3影响腭架融合的内在，主要机制，而不是继发于颅面缺损的影响。
Mice lacking IGF-beta 3 exhibit an incompletely penetrant failure of the palatal shelves to fuse leading to cleft palate. The defect appears to result from impaired adhesion of the apposing medial edge epithelia of the palatal shelves and subsequent elimination of the mid-line epithelial seam. No craniofacial abnormalities were observed. This result demonstrates that TGF-beta 3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.