CTGA: the database for genetic disorders in Arab populations
CTGA: the database for genetic disorders in Arab populations
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DOI：
10.1093/nar/gkj015
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发表时间：
2006-01-01
影响因子：
14.9
通讯作者：
Al Khaja, Najib
中科院分区：
文献类型：
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作者：
Tadmouri, Ghazi O.;Al Ali, Mahmoud Taleb;Al Khaja, Najib
阿拉伯人组成了一个遗传上不同的群体，这是历史上不同人口混杂的结果。它们有许多共同特征，导致相当大比例的围产期和新生儿死亡。为此，阿拉伯基因组研究中心(CAGS)启动了一个试点项目，以构建“阿拉伯人遗传遗传目录”(CTGA)阿拉伯人遗传病数据库。CTGA中的信息来自已发表的研究和挖掘的医院记录。该数据库提供了基于网络的基本和高级搜索方法。在这两种情况下，最终的搜索结果都是一个详细的HTML记录，其中包括基于文本、URL和图形的字段。目前，CTGA拥有阿拉伯个体描述的692个表型和235个相关基因的条目。其中，在阿拉伯联合酋长国(阿联酋)的阿拉伯人口中观察到了213个表型描述和22个相关基因。这些结果强调了CTGA作为促进该区域遗传疾病科学研究的重要工具的作用。CTGA的优先事项是及时提供关于阿拉伯个人遗传病发生情况的信息。预计将对阿联酋以外的阿拉伯国家的数据进行详尽的检索，并将其纳入CTGA(http://www.cags.org.ae).
The Arabs comprise a genetically heterogeneous group that resulted from the admixture of different populations throughout history. They share many common characteristics responsible for a considerable proportion of perinatal and neonatal mortalities. To this end, the Centre for Arab Genomic Studies (CAGS) launched a pilot project to construct the 'Catalogue of Transmission Genetics in Arabs'(CTGA) database for genetic disorders in Arabs. Information in CTGA is drawn from published research and mined hospital records. The database offers web-based basic and advanced search approaches. In either case, the final search result is a detailed HTML record that includes text-, URL- and graphic-based fields. At present, CTGA hosts entries for 692 phenotypes and 235 related genes described in Arab individuals. Of these, 213 phenotypic descriptions and 22 related genes were observed in the Arab population of the United Arab Emirates (UAE). These results emphasize the role of CTGA as an essential tool to promote scientific research on genetic disorders in the region. The priority of CTGA is to provide timely information on the occurrence of genetic disorders in Arab individuals. It is anticipated that data from Arab countries other than the UAE will be exhaustively searched and incorporated in CTGA (http://www.cags.org.ae).