Renal function in streptozotocin-diabetic rats
Renal function in streptozotocin-diabetic rats
复制标题
链脲佐菌素糖尿病大鼠的肾功能
作者：
P. K. Jensen;J. Christiansen;K. Steven;H. Parving
摘要用微穿刺方法检查了经胰岛素治疗的链脲佐菌素糖尿病大鼠的肾功能。糖尿病大鼠的肾小球滤过率（1.21ml/min）显着高于对照组（0.84ml/min）。肾单位肾小球滤过率随着肾小球滤过率的升高而增加（糖尿病大鼠：37.0nl/min；对照大鼠：27.9nl/min）。同样，糖尿病大鼠的肾血浆流量（4.1 毫升/分钟）显着高于对照组（3.0 毫升/分钟）。两组的肾小球毛细血管压力相同（分别为 56.0 和 56.0 mmHg）。糖尿病大鼠的近端肾小管内压力显着降低（10.4 mmHg；对照值：12.5 mmHg）。糖尿病组大鼠的有效肾小球超滤系数（0.027 nl s-1mmHg-1）略高于对照组（0.023 nl s-1mmHg-1），但不显着。糖尿病大鼠的肾脏重量显着较高（1.15 克；对照大鼠：0.96 克），而两组的体重相似（糖尿病大鼠：232 克；对照大鼠：238 克）。计算表明，肾小球水压、肾血浆流量和肾小球膜超滤系数的增加对肾小球滤过率的增加贡献大致相同。肾小球滤过率决定因素值的增加可能是肾肥大的结果。这些研究表明，该模型为研究糖尿病肾功能提供了一种有用的方法，这可能与我们了解人类糖尿病肾异常有关。
SummaryRenal function was examined with micropuncture methods in the insulin-treated streptozotocin-diabetic rat. Kidney glomerular filtration rate was significantly higher in the diabetic rats (1.21 ml/min) than in the control group (0.84 ml/min) Nephron glomerular filtration rate increased in proportion to the rise in kidney glomerular filtration rate (diabetic rats: 37.0 nl/min; control rats: 27.9 nl/min). Likewise renal plasma flow was significantly higher in the diabetic rats (4.1 ml/min) than in the control group (3.0 ml/min). Glomerular capillary pressure was identical in both groups (56.0 and 56.0 mmHg, respectively). The proximal intratubular pressure was significantly reduced in the diabetic rats (10.4 mmHg; control value: 12.5 mmHg). The effective glomerular ultrafiltration coefficient was slightly but not significantly higher in the diabetic rats (0.027 nl s-1mmHg-1) than in the control group (0.023 nl s-1mmHg-1). Kidney weight was significantly higher in the diabetic rats (1.15 g; control rats: 0.96 g) while body weight was similar in both groups (diabetic rats: 232 g; control rats: 238 g). Calculations indicate that the increases in transglomerular hydraulic pressure, renal plasma flow and ultrafiltration co-efficient of the glomerular membrane contribute about equally to the rise in glomerular filtration rate. The increases in the values of the determinants of glomerular filtration rate may be the result of renal hypertrophy. These studies suggest that this model provides a useful method for investigating kidney function in diabetes, which may have relevance for our understanding of the kidney abnormalities in human diabetes.