Dimethyl sulfoxide stimulates tyrosine residue phosphorylation of rat liver epidermal growth factor receptor.
Dimethyl sulfoxide stimulates tyrosine residue phosphorylation of rat liver epidermal growth factor receptor.
复制标题
二甲亚砜刺激大鼠肝表皮生长因子受体酪氨酸残基磷酸化。
DOI：
10.1126/science.6294827
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Earp,HS
中科院分区：
文献类型：
--
作者：
Rubin,RA;Earp,HS
表皮生长因子是一种有效的有丝分裂原，可刺激其17万道尔顿质膜受体的磷酸化。二甲基亚砜选择性地增加大鼠肝微粒体部分表皮生长因子受体的磷酸化。当二甲亚砜浓度为15%至25%时，刺激效果达到最大，其强度和速度与表皮生长因子相似。与表皮生长因子一样，二甲基亚砜选择性地刺激该蛋白的酪氨酸残基磷酸化。
Epidermal growth factor, a potent mitogen, stimulates phosphorylation of its 170,000-dalton plasma membrane receptor. Dimethyl sulfoxide selectively increased phosphorylation of the epidermal growth factor receptor in rat liver microsomal fraction. Maximal stimulation occurred at 15 to 25 percent dimethyl sulfoxide and resembled the effect of epidermal growth factor in magnitude and rapidity. Like epidermal growth factor, dimethyl sulfoxide selectively stimulated tyrosine residue phosphorylation of this protein.