Evaluating retinal vessel diameter with optical coherence tomography in normal-tension glaucoma patients
Evaluating retinal vessel diameter with optical coherence tomography in normal-tension glaucoma patients
复制标题
用光学相干断层扫描评估正常眼压青光眼患者的视网膜血管直径
DOI：
10.1007/s10384-017-0523-z
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发表时间：
2017
影响因子：
2.4
通讯作者：
Toru Nakazawa
中科院分区：
文献类型：
--
作者：
Takeshi Yabana;Yukihiro Shiga;Ryo Kawasaki;Kazuko Omodaka;Hidetoshi Takahashi;Koudai Kimura;Kyosuke Togashi;Takaaki Horii;Kei Sasaki;Testuya Yuasa;Toru Nakazawa
目的研究一种新的光学相干断层扫描（OCT）衍生变量--视乳头周围平均视网膜阴影宽度（cpMRSW），并阐明其与正常眼压性青光眼（NTG）的关系。我们测量了12名NTG患者和12名健康受试者的68个小动脉和100个小静脉的视网膜血管口径，并比较了光谱中可见视网膜阴影的宽度，域OCT图像和视网膜照片中视网膜血管的口径。然后计算78只NTG眼和25只年龄匹配的健康对照眼的cpMRSW。此外，我们将患者分为早期（平均偏差：MD > −6 dB）、中度（MD −6至−12 dB）和重度（MD < −12 dB）NTG组，并比较这些组中的cpMRSW。结果OCT视网膜阴影宽度与OCT测量的视网膜口径呈显著正相关（r = 0.82，P < 0.001），视网膜阴影宽度与OCT测量的视网膜口径呈显著正相关（r= 0.82，P < 0.001）。对照组和NTG患者的CpMRSW显著不同（对照组：107.3 ± 7.0 µm，轻度：99.4 ± 8.6 µm，中度：99.7 ± 9.5 µm，重度：90.5 ± 12.0 µm，P< 0.001），尽管全身变量的分布相似。ROC分析显示，cpMRSW可以区分NTG正常眼（ROC曲线下面积：0.81）。结论我们的新软件测量平均视网膜阴影宽度OCT图像可能是一个有价值的工具，检测NTG和诊断其严重性。
PurposeTo investigate a novel optical coherence tomography (OCT)-derived variable, circumpapillary mean retinal shadow width (cpMRSW), and to elucidate its association with normal-tension glaucoma (NTG).MethodsFor the purpose of validation, we measured retinal vascular calibers in 68 arterioles and 100 venules of 12 NTG patients and 12 healthy subjects and compared the width of the visible retinal shadows in spectral-domain OCT images and the caliber of retinal vessels in retinal photographs. Then we calculated cpMRSW in 78 NTG eyes and 25 age-matched healthy control eyes. Additionally, we divided the patients into early (mean deviation: MD > −6 dB), moderate (MD −6 to −12 dB), and severe (MD < −12 dB) NTG groups, and compared cpMRSW in these groups. Finally, we calculated the area under the receiver operating characteristic (ROC) curve in order to determine the power of mean retinal shadow width to distinguish the groups.ResultsOCT retinal shadow width was significantly correlated with photography-measured retinal caliber (r= 0.82,P< 0.001). CpMRSW was significantly different between the control and NTG patients (control: 107.3 ± 7.0 µm, mild: 99.4 ± 8.6 µm, moderate: 99.7 ± 9.5 µm, severe: 90.5 ± 12.0 µm,P< 0.001), despite similar distributions in systemic variables. An ROC analysis revealed that cpMRSW could differentiate NTGs from normal eyes (area under the ROC curve: 0.81).ConclusionsOur new software for measuring mean retinal shadow width in OCT images may be a valuable tool for detecting NTG and diagnosing its severity.