Functional, imaging, and respiratory evaluation (FIRE) of patients post-hospitalization for COVID-19: protocol for a pilot observational study.
Functional, imaging, and respiratory evaluation (FIRE) of patients post-hospitalization for COVID-19: protocol for a pilot observational study.
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DOI：
10.1186/s40814-022-01151-8
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发表时间：
2022-09-19
影响因子：
1.7
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中科院分区：
文献类型：
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我们描述了一种用于火珊瑚的方案，这是一项观察性队列研究，检查了急性住院后新冠肺炎病的康复情况，重点是功能、成像和呼吸评估。Fire Coral是一项多中心前瞻性队列研究，参与者从新冠肺炎病中康复，并由国家心肺血液研究所(NHLBI)急性肺损伤(PEAL)预防和早期治疗网络对功能和肺表型进行面对面随访。Fire Coral将包括参加花瓣新冠肺炎观察研究(蓝珊瑚)生物学和纵向流行病学的参与者子集，这是一项由NHLBI资助的前瞻性队列研究，描述了花瓣网络中新冠肺炎住院患者的临床特征、治疗、生物学和结果。Fire Coral由一系列面对面的评估组成，这些评估客观地测量肺功能、肺成像异常、身体功能状态和生物谱分析。参与者将在住院后3至9个月参加并进行初步面对面测试。该研究的主要目标是确定对新冠肺炎回收的多个领域进行纵向评估的可行性。其次，我们将进行描述性统计，包括肺功能、胸部影像和功能状态异常的发生率和特征。我们还将确定预测肺功能、胸部影像和功能状态恢复或发生持续性损害的潜在临床和生物因素。火珊瑚通过范德比尔特大学中央机构审查委员会(IRB)和与现场IRBS的信实协议获得批准。结果将通过议定书委员会的编写小组分发，并在出版前由PEATAL网络出版物委员会审查。通过这项研究获得的数据随后将通过NHLBI的生物信息库公开提供。首次在美国对以前因新冠肺炎感染住院的患者的肺和功能结果进行多中心队列研究纵向生物显微镜测量，允许对不同地理位置的异常队列进行生物表型分析，从而对COVID后肺部后遗症的强度有更普遍的了解：选定的队列靠近参与中心的小队列，可能无法识别肺功能限制的微小变化：
We describe a protocol for FIRE CORAL, an observational cohort study that examines the recovery from COVID-19 disease following acute hospitalization with an emphasis on functional, imaging, and respiratory evaluation. FIRE CORAL is a multicenter prospective cohort study of participants recovering from COVID-19 disease with in-person follow-up for functional and pulmonary phenotyping conducted by the National Heart, Lung and Blood Institute (NHLBI) Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. FIRE CORAL will include a subset of participants enrolled in Biology and Longitudinal Epidemiology of PETAL COVID-19 Observational Study (BLUE CORAL), an NHLBI-funded prospective cohort study describing the clinical characteristics, treatments, biology, and outcomes of hospitalized patients with COVID-19 across the PETAL Network. FIRE CORAL consists of a battery of in-person assessments objectively measuring pulmonary function, abnormalities on lung imaging, physical functional status, and biospecimen analyses. Participants will attend and perform initial in-person testing at 3 to 9 months after hospitalization. The primary objective of the study is to determine the feasibility of longitudinal assessments investigating multiple domains of recovery from COVID-19. Secondarily, we will perform descriptive statistics, including the prevalence and characterization of abnormalities on pulmonary function, chest imaging, and functional status. We will also identify potential clinical and biologic factors that predict recovery or the occurrence of persistent impairment of pulmonary function, chest imaging, and functional status. FIRE CORAL is approved via the Vanderbilt University central institutional review board (IRB) and via reliance agreement with the site IRBs. Results will be disseminated via the writing group for the protocol committee and reviewed by the PETAL Network publications committee prior to publication. Data obtained via the study will subsequently be made publicly available via NHLBI’s biorepository. First US-based multicenter cohort of pulmonary and functional outcomes in patients previously hospitalized for COVID-19 infection Longitudinal biospecimen measurement allowing for biologic phenotyping of abnormalities Geographically diverse cohort allowing for a more generalizable understanding of post-COVID pulmonary sequela Strengths: Selected cohort given proximity to a participating center Small cohort which may be underpowered to identify small changes in pulmonary function Limitations: