Antibiotic resistance in a very remote Amazonas community
Antibiotic resistance in a very remote Amazonas community
复制标题
DOI：
10.1016/j.ijantimicag.2008.07.029
复制
发表时间：
2009-02-01
影响因子：
10.8
通讯作者：
Rossolini, Gian Maria
中科院分区：
文献类型：
--
作者：
Bartoloni, Alessandro;Pallecchi, Lucia;Rossolini, Gian Maria
在秘鲁亚马逊河流域一个极少接触抗生素的非常偏远的人类社区，在共生的大肠杆菌中发现了对最古老的抗生素（氨苄西林、四环素、甲氧苄啶/磺胺甲新唑、链霉素和氯霉素）的高度获得性耐药性，具有显著多样性的耐药克隆和耐药基因和质粒。这种模式总体上与之前在玻利维亚一个非常偏远的社区观察到的情况相似。它也与最近的城市地区所观察到的情况相似，除了在偏远社区耐药分离株的优势较低和绝对缺乏喹诺酮类药物耐药性。目前的研究结果表明，在抗生素接触最少的偏远社区观察到的抗生素耐药性是一种由复杂机制促成的普遍现象，并为这一现象所涉及的机制提供了新的见解。(C) 2008 Elsevier b.v.与International Society of Chemotherapy。版权所有。
In a very remote human community of the Peruvian Amazonas with minimal antibiotic exposure, high levels of acquired resistance to the oldest antibiotics ( ampicillin, tetracycline, trimethoprim/sulfamethoxazole, streptomycin and chloramphenicol) were detected in commensal Escherichia coli, with remarkable diversity of resistant clones and of resistance genes and plasmids. This pattern was similar overall to that previously observed in a very remote community of Bolivia. It was also similar to that observed in the nearest urban area, except for a lower dominance of resistant isolates and the absolute lack of quinolone resistance in the remote community. Present findings suggest that antibiotic resistance observed in remote communities with minimal antibiotic exposure is a general phenomenon contributed by complex mechanisms and provide new insights into the mechanisms involved in this phenomenon. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.