The class IHLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G
The class IHLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G
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DOI：
10.2337/db05-0731
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发表时间：
2006-05-01
期刊：
影响因子：
7.7
通讯作者：
Crisa, L
中科院分区：
文献类型：
--
作者：
Cirulli, V;Zalatan, J;Crisa, L
人Ib类HLA分子HLA- g在免疫保护部位的选择性表达及其抑制NK和t细胞效应功能的功能支持该分子在免疫调节中的重要作用。在这里，我们证明HLA-G在人胰腺的内分泌室中组成性表达。HLA决定因子在内分泌细胞中的表面表达。受生长和炎症刺激的调节。此外，我们提供的证据表明，在该组织中表达的HLA-G可能与含胰岛素颗粒的一个子集相关，并可能在分泌刺激下穿梭到细胞表面。因此，内分泌细胞的HLA-G呈递可能受到与其分泌活性一致的调节。这些结果确定了一个主要的组织相容性复合体位点的表达，在人类胰岛中具有假定的调节功能，这一发现对自身免疫的进展以及对该组织移植耐受的建立具有潜在的重要意义。
Selective expression of the human class Ib HLA molecule HLA-G in immunologically protected sites and its function in the inhibition of NK and T-cell effector functions support an important role of this molecule in immunoregulation. Here, we demonstrate that HLA-G is constitutively expressed in the endocrine compartment of the human pancreas. Surface expression of this HLA determinant in endocrine cells. is regulated in response to growth and inflammatory stimuli. Furthermore, we provide evidence that HLA-G expressed in this tissue may associate with a subset of insulin-containing granules and may be shuttled to the cell surface in response to secretory stimuli. Thus, HLA-G presentation by endocrine cells may be regulated in concert with their secretory activity. These results identify the expression of a major histocompatibility complex locus with putative regulatory functions in human pancreatic islets, a finding with potentially important implications for the progression of autoimmunity as well as for the estab- lishment of transplant tolerance to this tissue.