Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents
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DOI：
10.1038/s41593-021-00800-0
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发表时间：
2021-02-15
影响因子：
25
通讯作者：
Charlet, Alexandre
中科院分区：
文献类型：
--
作者：
Wahis, Jerome;Baudon, Angel;Charlet, Alexandre
催产素（OT）通过调节神经回路来协调社会和情感行为。在中央杏仁核中，OT的释放调节抑制回路，从而抑制恐惧反应并降低焦虑水平。使用星形胶质细胞特定的增益和功能和药理学方法的损失，我们表明，一个形态上不同的星形胶质细胞亚群表达OT受体和介导的抗焦虑和积极的强化作用OT在中央杏仁核的小鼠和大鼠。星形胶质细胞参与OT信号传导挑战了长期以来的教条，即OT只作用于神经元，并强调星形胶质细胞是正常和慢性疼痛条件下调节情绪状态的重要组成部分。
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.