Method for Novel 3D Bioprinting of Gradient Scaffold for Osteochondral Regeneration Using a Coaxial Multi-Nozzle and Software
Method for Novel 3D Bioprinting of Gradient Scaffold for Osteochondral Regeneration Using a Coaxial Multi-Nozzle and Software
复制标题
使用同轴多喷嘴和软件进行骨软骨再生梯度支架的新型 3D 生物打印方法
DOI：
10.1166/jbt.2019.1954
复制
发表时间：
2019
影响因子：
0.1
通讯作者：
Zhang Haiguang
中科院分区：
文献类型：
--
作者：
Hu Qingxi;Jiang Biao;Zhang Haiguang
生物3D打印伴随着3D打印技术在医疗领域的兴起。生物3D打印支架和血管的应用尤其广泛。本文重点介绍了目前多材料、多梯度支架不能很好地集成的缺点。设计并开发了一种多材料、多梯度的生物支架集成打印系统。在切片软件生成的打印信息中加入标签信息，然后利用新设计的多喷嘴同轴喷嘴成型骨软骨支架等梯度生物材料支架。HUVECs被成功地封装到骨软骨支架中并保持活力。这些结果表明，分层梯度支架具有修复骨软骨缺损的潜力。
Biological 3D printing is accompanied by the rise of 3D printing technology in the medical field. The applications of biological 3D printing stents and blood vessels are particularly extensive. This paper focuses on the shortcomings of multi-material and multi-gradient scaffolds that can not be well integrated at present. A multi-material and multi-gradient integrated printing system for bio-scaffolds is designed and developed. The label information is added to the printing information generated by the slicing software, and then the gradient biomaterial scaffolds such as osteochondral scaffolds are formed by using the newly designed multi-nozzle coaxial nozzle. HUVECs were successfully encapsulated into the osteochondral scaffolds and remained viable. These results demonstrate that stratified gradient scaffolds have the potential to repair osteochondral defects.