Titania-containing bioactive bone cement for total hip arthroplasty in dogs
Titania-containing bioactive bone cement for total hip arthroplasty in dogs
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DOI：
10.1002/jbm.b.34216
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发表时间：
2019-05-01
影响因子：
3.4
通讯作者：
Matsuda, Shuichi
中科院分区：
文献类型：
--
作者：
Imamura, Masashi;Goto, Koji;Matsuda, Shuichi
我们开发了一种复合骨水泥，其中含有低含量的生物活性二氧化钛填料分散在特定的聚甲基丙烯酸甲酯（PMMA）聚合物和研究的力学性能和生物活性，这种二氧化钛骨水泥（TBC）在成年雌性比格犬骨水泥全髋关节置换术（THA）的承重条件下。使用定制的假体比较TBC和PMMA骨水泥（PBC）。术后1、3、6和12个月处死犬。获取髋臼以评价骨水泥的骨传导性，而获取股骨用于推出试验和组织学分析。TBC的抗压强度显著高于PBC（p < 0.001），而弯曲和拉伸强度以及断裂韧性相当。TBC和PBC的粘合强度值在1个月时分别为72.9和58.0 N/mm，在3个月时分别为69.4和57.2 N/mm，在6个月时分别为106.1和85.0 N/mm，在12个月时分别为114.3和100.7 N/mm。在组织学上，TBC与骨直接接触，在较大区域上没有纤维组织介入，并且沿骨水泥沿着观察到新形成的骨。这种新型骨水泥具有良好的力学性能和生物活性，具有潜在的临床应用价值。(c)2018 Wiley Periodicals，Inc. J Biomed Mater Res Part B：Appl Biomater 107 B：1238-1245，2019。
We developed a composite cement containing low-content bioactive titania fillers dispersed among specific polymethylmethacrylate (PMMA) polymers and investigated the mechanical properties and bioactivity of this titania bone cement (TBC) under load-bearing conditions in cemented total hip arthroplasty (THA) in adult female beagles. TBC and PMMA bone cement (PBC) were compared using custom-made prostheses. The dogs were killed 1, 3, 6, and 12 months postoperatively. The acetabulum was harvested to evaluate the osteoconductivity of the cement, whereas the femur was harvested for the push-out test and histological analyses. The compressive strength of TBC was significantly higher than that of PBC (p < 0.001), whereas the flexural and tensile strengths, as well as fracture toughness, were equivalent. The bonding strength values for TBC and PBC were 72.9 and 58.0 N/mm at 1 month, 69.4 and 57.2 N/mm at 3 months, 106.1 and 85.0 N/mm at 6 months, and 114.3 and 100.7 N/mm at 12 months, respectively. Histologically, TBC was in direct contact with bone without intervening with fibrous tissue over larger areas and newly formed bone was observed along the cement. The excellent mechanical properties and apparent bioactivity of this novel bone cement indicate its potential utility in clinical practice. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1238-1245, 2019.