Regulation of production and secretion of adrenomedullin in the cardiovascular system
Regulation of production and secretion of adrenomedullin in the cardiovascular system
复制标题
DOI：
10.1016/s0167-0115(03)00023-5
复制
发表时间：
2003-04-15
影响因子：
--
通讯作者：
Kitamura, K
中科院分区：
文献类型：
--
作者：
Eto, T;Kato, J;Kitamura, K
肾上腺髓质素（AM）具有多种功能，其中最具特点的是血管舒张降压作用。AM及其基因普遍存在于各种组织和器官、心血管系统以及肾上腺髓质中。AM的分泌，尤其是在心血管组织中，主要受剪切应力等机械应激源、白细胞介素(IL)-1、肿瘤坏死因子（TNF）和脂多糖（LPS）等炎症因子、血管紧张素（Ang） II和内皮素(ET)-1等激素以及缺氧、缺血或高血糖等代谢因素的调节。在病理条件下，由于对一种或多种刺激的反应而产生的血浆AM的升高可以解释在心血管和肾脏疾病（如充血性心力衰竭、心肌梗死、高血压、慢性肾衰竭、中风、糖尿病和感染性休克）中存在的血浆AM水平升高。除了剪切应力外，心肌细胞的拉伸可能是AM合成和分泌的另一种机械刺激。我们最近的研究表明醛固酮和其他激素因子对血管壁AM分泌的重要性。(C) 2003年Elsevier Science B.V.出版
Adrenomedullin (AM) has multi-functional properties, of which the vasodilatory hypotensive effect is the most characteristic. AM and its gene are ubiquitous in a variety of tissues and organs, in the cardiovascular system, as well as the adrenal medulla. AM secretion, especially in cardiovascular tissues, is regulated mainly by mechanical stressors such as shear stress, inflammatory cytokines such as interleukin (IL)-1, tumor necrosis factor (TNF), and lipopolysaccharide (LPS), hormones such as angiotensin (Ang) II and endothelin (ET)-1, and metabolic factors such as hypoxia, ischemia, or hyperglycemia. Elevation of plasma AM due to overproduction in response to one or more of these stimuli in pathological conditions may explain the raised plasma AM levels present in cardiovascular and renal diseases such as congestive heart failure, myocardial infarction, hypertension, chronic renal failure, stroke, diabetes mellitus, and septic shock. In addition to shear stress, stretching of cardiomyocytes may be another mechanical stimulus for AM synthesis and secretion. Our recent studies have shown the importance of aldosterone and additional hormonal factor on AM secretion in vascular wall. (C) 2003 Published by Elsevier Science B.V.