Gut Microbiota and Obesity
Gut Microbiota and Obesity
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DOI：
10.7704/kjhugr.2023.0057
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发表时间：
2023-12
影响因子：
--
通讯作者：
Seung Young Kim
中科院分区：
文献类型：
--
作者：
Seung Young Kim
肥胖是一个全球性的健康问题，与广泛的疾病有关，包括糖尿病、代谢综合征、脂肪肝和心血管疾病。最近的研究强调了肠道微生物群在肥胖中的重要作用。研究表明，在被诊断患有肥胖症的个体中，肠道微生物群的组成和多样性发生了显着变化。肠道菌群参与能量代谢、脂质合成和炎症调节，因此在肥胖的发病机制中起关键作用。基于使用益生菌、益生元、嗜粘蛋白阿克曼氏菌和粪便微生物群移植的治疗方法在动物研究中显示出作为对抗肥胖和代谢综合征的有用策略的前景。然而，进一步的研究是有必要的，以最终建立特定的菌株，剂量和机制的有效性，这些新的战略对人类肥胖。
Obesity is a global health concern associated with a wide range of diseases, including diabetes, metabolic syndrome, fatty liver, and cardiovascular conditions. Recent studies highlight the significant role of gut microbiota in obesity. Research indicates notable changes in the composition and diversity of gut microbiota in individuals diagnosed with obesity. The gut microbiota participate in energy metabolism, lipid synthesis, and regulation of inflammation and therefore play a key role in the pathogenesis of obesity. Therapeutic approaches based on the use of probiotics, prebiotics, Akkermansia muciniphila, and fecal microbiota transplantation have shown promise in animal studies as useful strategies against obesity and metabolic syndrome. However, further research is warranted to conclusively establish the specific strains, dosages, and mechanisms underlying the effectiveness of these novel strategies against obesity in humans.