CURRENT INJECTION INTO A TWO-DIMENSIONAL ANISOTROPIC BIDOMAIN
CURRENT INJECTION INTO A TWO-DIMENSIONAL ANISOTROPIC BIDOMAIN
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DOI：
10.1016/s0006-3495(89)82897-8
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发表时间：
1989-05-01
影响因子：
3.4
通讯作者：
WIKSWO, JP
中科院分区：
文献类型：
--
作者：
SEPULVEDA, NG;ROTH, BJ;WIKSWO, JP
用二维各向异性心脏组织片模型表示心脏组织，用有限元法求解二维各向异性心脏组织片模型方程。当细胞内和细胞外空间的各向异性比不相等时，将电流注入到组织中诱导具有复杂空间依赖性的跨膜电位，包括去极化和超极化组织的相邻区域。这种行为可能对心脏组织的电刺激和除颤具有重要意义。
A two-dimensional sheet of anisotropic cardiac tissue is represented with the bidomain models, and the finite element method is used to solve the bidomain equations. When the anisotropy ratios of the intracellular and extracellular spaces are not equal, the injection of current into the tissue induces a transmembrane potential that has a complicated spatial dependence, including adjacent regions of depolarized and hyperpolarized tissue. This behavior may have important implications for the electrical stimulation of cardiac tissue and for defibrillation.