Failure of the Mycobacterium bovis BCG vaccine:: Some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis
Failure of the Mycobacterium bovis BCG vaccine:: Some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis
复制标题
DOI：
10.1128/iai.70.2.672-678.2002
复制
发表时间：
2002-02-01
影响因子：
3.1
通讯作者：
Andersen, P
中科院分区：
文献类型：
--
作者：
Brandt, L;Cunha, JF;Andersen, P
卡介苗（MycobacteriumbovisbacillusCalmette-Guerin，BCG）对肺结核（tuberculosis，TB）的疗效在不同人群中差异很大。流行的假设将这种变异归因于疫苗与环境中常见的分枝杆菌之间的相互作用，但确切的机制迄今尚未阐明。我们的研究表明，事先暴露于活的环境分枝杆菌可以导致广泛的免疫反应，在卡介苗接种后迅速召回，并控制疫苗的繁殖。在这些致敏小鼠中，BCG仅激发短暂的免疫应答，分枝杆菌特异性细胞的频率较低，对结核病没有保护性免疫。相反，结核亚单位疫苗的效力不受先前暴露于环境分枝杆菌的影响。在小鼠模型中研究了来自北方马拉维Karonga区（BCG疫苗接种对肺结核无效的地区）的土壤和痰样品的6种不同分离株，发现两种鸟分枝杆菌复合物菌株完全阻断BCG活性。
The efficacy of Mycobacterium bovis bacillus Calmette-Guerin (BCG) vaccine against pulmonary tuberculosis (TB) varies enormously in different populations. The prevailing hypothesis attributes this variation to interactions between the vaccine and mycobacteria common in the environment, but the precise mechanism has so far not been clarified. Our study demonstrates that prior exposure to live environmental mycobacteria can result in a broad immune response that is recalled rapidly after BCG vaccination and controls the multiplication of the vaccine. In these sensitized mice, BCG elicits only a transient immune response with a low frequency of mycobacterium-specific cells and no protective immunity against TB. In contrast, the efficacy of TB subunit vaccines was unaffected by prior exposure to environmental mycobacteria. Six different isolates from soil and sputum samples from Karonga district in Northern Malawi (a region in which BCG vaccination has no effect against pulmonary TB) were investigated in the mouse model, and two strains of the Mycobacterium avium complex were found to block BCG activity completely.