Examining social genetic effects on educational attainment via parental educational attainment, income, and parenting.
Examining social genetic effects on educational attainment via parental educational attainment, income, and parenting.
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DOI：
10.1037/fam0001003
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发表时间：
2022-12
影响因子：
2.7
通讯作者：
Dick, Danielle M
中科院分区：
文献类型：
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作者：
Su, Jinni;Kuo, Sally I-Chun;Trevino, Angel;Barr, Peter B;Aliev, Fazil;Bucholz, Kathleen;Chan, Grace;Edenberg, Howard J;Kuperman, Samuel;Lai, Dongbing;Meyers, Jacquelyn L;Pandey, Gayathri;Porjesz, Bernice;Dick, Danielle M
父母受教育程度越高，子女受教育程度越高。在这项研究中，我们结合了来自父亲、母亲和后代的基因型和表型信息，以解开这种关联背后的遗传和社会环境途径。数据来自酗酒遗传学合作研究的欧洲血统个体样本（n = 4,089, 51%为女性）。通径分析结果表明，父系和母系受教育程度全基因组多基因得分与后代受教育程度存在显著的相关关系，且超过了后代受教育程度多基因得分的影响。父母受教育程度、收入和父母行为是中介父母受教育多基因得分对后代受教育程度影响的重要社会环境途径。我们的研究强调了利用遗传信息的家庭研究来解开父母对人类发展影响的遗传和社会环境途径的重要性。
Higher parental educational attainment is associated with higher offspring educational attainment. In this study, we incorporated genotypic and phenotypic information from fathers, mothers, and offspring to disentangle the genetic and socio-environmental pathways underlying this association. Data were drawn from a sample of individuals of European ancestry from the Collaborative Study on the Genetics of Alcoholism (n = 4,089; 51% female). Results from path analysis indicated that paternal and maternal educational attainment genome-wide polygenic scores were associated with offspring educational attainment, above and beyond the effect of offspring education polygenic score. Parental educational attainment, income, and parenting behaviors served as important socio-environmental pathways that mediated the effect of parental education polygenic score on offspring educational attainment. Our study highlights the importance of using genetically informed family studies to disentangle the genetic and socio-environmental pathways underlying parental influences on human development.