Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3
Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3
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DOI：
10.1038/nature02739
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发表时间：
2004-07-22
期刊：
影响因子：
64.8
通讯作者：
Knierim, JJ
中科院分区：
文献类型：
--
作者：
Lee, I;Yoganarasimha, D;Knierim, JJ
海马体是导航、情境依赖学习和情景记忆的关键大脑结构（1-3），由解剖学上不同的亚区组成。这些区域在解剖输入和内部电路上都有所不同(4)。CA3区域的一个主要特征是它的循环侧支回路，通过它，CA3锥体细胞彼此之间产生兴奋性突触接触（4,5）。相反，CA1区的锥体细胞没有广泛的相互连接(4)。尽管这些差异激发了许多关于这两个区域的不同处理能力的理论模型（6-13），但很少有关于CA1和CA3神经元在行为动物中的放电特性存在显著差异的报道。这些特性中研究最广泛的是海马“位置细胞”的空间选择性放电（1,14）。在动态变化的环境中，行为轨迹上和墙壁上熟悉的地标相互旋转（15,16），在CA3中，环境的种群表示在原始和线索改变的环境之间比在CA1中更加一致。这些结果表明CA3和CA1的位置细胞在神经群体表征水平上存在功能异质性。
The hippocampus, a critical brain structure for navigation, context-dependent learning and episodic memory(1-3), is composed of anatomically heterogeneous subregions. These regions differ in their anatomical inputs as well as in their internal circuitry(4). A major feature of the CA3 region is its recurrent collateral circuitry, by which the CA3 pyramidal cells make excitatory synaptic contacts on each other(4,5). In contrast, pyramidal cells in the CA1 region are not extensively interconnected(4). Although these differences have inspired numerous theoretical models of differential processing capacities of these two regions(6-13), there have been few reports of robust differences in the firing properties of CA1 and CA3 neurons in behaving animals. The most extensively studied of these properties is the spatially selective firing of hippocampal 'place cells'(1,14). Here we report that in a dynamically changing environment, in which familiar landmarks on the behavioural track and along the wall are rotated relative to each other(15,16), the population representation of the environment is more coherent between the original and cue-altered environments in CA3 than in CA1. These results demonstrate a functional heterogeneity between the place cells of CA3 and CA1 at the level of neural population representations.