IMMUNOHISTOCHEMICAL IDENTIFICATION OF PROSTATIC ACID-PHOSPHATASE - CORRELATION OF TUMOR GRADE WITH ACID-PHOSPHATASE DISTRIBUTION
IMMUNOHISTOCHEMICAL IDENTIFICATION OF PROSTATIC ACID-PHOSPHATASE - CORRELATION OF TUMOR GRADE WITH ACID-PHOSPHATASE DISTRIBUTION
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DOI：
10.1016/s0022-5347(17)53915-4
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发表时间：
1982-01-01
影响因子：
6.6
通讯作者：
LIN, CW
中科院分区：
文献类型：
--
作者：
BATES, RJ;CHAPMAN, CM;LIN, CW
用免疫组织化学方法研究了[人]前列腺特异性酸性磷酸酶(PSAP)在正常前列腺、前列腺增生症和前列腺癌中的定位和分布。PSAP在正常和增生性前列腺腺上皮中强而均一的染色。在前列腺癌中，PSAP染色与分化程度和肿瘤成腺能力相关：高分化腺癌PSAP染色较均一，而低分化腺癌PSAP染色较弱且多变。在转移到淋巴结和其他器官的肿瘤中也观察到了同样的相关性。
The localization and distribution of [human] prostatic specific acid phosphatase (PSAP) in normal, hyperplastic and neoplastic prostates were studied by specific immunohistochemical methods. Strong and uniform PSAP staining was observed in the glandular epithelium of normal and hyperplastic prostates. In adenocarcinoma of the prostate, a correlation of the PSAP staining with the degree of differentiation and the ability of the tumor to form a gland was observed: more intense and uniform staining in well differentiated tumors and less intense and more variable stains in poorly differentiated tumors. The same correlation was also observed in tumors metastasized to lymph nodes and other organs.