Event-related potentials in adults with Attention-Deficit/Hyperactivity Disorder: An investigation using an inter-modal auditory/visual oddball task
Event-related potentials in adults with Attention-Deficit/Hyperactivity Disorder: An investigation using an inter-modal auditory/visual oddball task
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DOI：
10.1016/j.ijpsycho.2008.09.009
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发表时间：
2009-02-01
影响因子：
3
通讯作者：
Heaven, Patrick C. L.
中科院分区：
文献类型：
--
作者：
Barry, Robert J.;Clarke, Adam R.;Heaven, Patrick C. L.
本研究探讨了是否从一个跨模态古怪的任务ERP可以区分成人注意力缺陷/多动障碍（AD/HD）和控制。两组年龄匹配的年轻成年男性（18 AD/HD，18对照）提出了一个跨模态的oddball任务，其中一个反相棋盘是非目标视觉刺激（随机提出的80%的试验），和2000 Hz的音调是听觉目标（20%的试验）。刺激以固定的速率呈现（刺激开始时间为1.03秒），参与者被要求默默地计数所有目标。与对照组相比，AD/HD组对听觉靶点的P2振幅整体增强，N2振幅降低，靶点P3振幅无差异，对听觉靶点的N1振幅以及对视觉非靶点的P1、N1、132、N2和P3振幅存在地形差异。这些结果被解释为早期感觉处理障碍的成人AD/HD，这可能是部分克服通过努力的处理，反映在后来的内源性ERP组件。(C)2008 Elsevier B. V.保留所有权利。
This study investigated whether ERPs from an inter-modal oddball task could distinguish between adults with Attention-Deficit/Hyperactivity Disorder (AD/HD) and controls. Two age-matched groups of young adult males (18 AD/HD, 18 controls) were presented with an inter-modal oddball task in which a counter-phasing checkerboard was the non-target visual stimulus (randomly presented on 80% of trials), and a 2000 Hz tone was the auditory target (20% of trials). Stimuli were presented at a fixed rate (stimulus-onset asynchrony 1.03 s) and participants were required to silently count all targets. The AD/HD group showed globally enhanced P2 and reduced N2 amplitudes to auditory targets, with no differences in target P3, together with topographic differences in N1 to auditory targets, and P1, N1, 132, N2 and P3 to visual non-targets, compared with controls. These results were interpreted in terms of early sensory-processing impairments in adults with AD/HD, which may be partially overcome through effortful processing, as reflected in the later endogenous ERP components. (C) 2008 Elsevier B.V. All rights reserved.