Vascular calcification: a left-handed compliment for aging.
Vascular calcification: a left-handed compliment for aging.
复制标题
血管钙化：对衰老的左手恭维。
DOI：
10.1152/ajpheart.00300.2021
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Brewster,LukeP
中科院分区：
文献类型：
--
作者：
Brewster,LukeP
“你看起来和你的年龄相称不错”，“上帝保佑你的心”，随着我们年龄的增长，其他左撇子的恭维话也变得更加引人注目。但衰老是注定的吗，还是随着时间的推移会发生一些不同的事情？39当然，动脉是为顺应性而设计的。温克塞尔效应使来自左心室的40个能量高效的血液搏动，为41个动脉血流(整个身体的组织和器官)的最终使用者提供灌流。每42次心跳消耗的能量越少，左心室年龄越好，这些组织和器官43的血流越好。衰老会使动脉变硬，但运动可以使我们的动脉相对年轻(比44岁)1，支持衰老过程中可改变的途径。然而，钙化是一个终极目标，这些节能机器(动脉)的45次钙化消除了温克塞尔效应，46次改变了一切2、3。事实上，动脉钙化可能是47岁和患有心血管疾病的人死亡的主要驱动因素4。48因此，动脉钙化是一个非常重要的话题，这篇社论是为了承认49由特别高产的MacTaggart-Kamenskiy 50实验室为文献增添的令人兴奋的内容5。使用大型临床影像数据库，作者描述了内布拉斯加州奥马哈周围52区患者动脉壁的变化和钙化与年龄的关系。这是对文献的重要补充，也是我们对动脉钙化这一最令人困惑的动脉病理之一的理解的基石。54
“You look good for your age,”“bless your heart,” and other left-handed compliments become 38 more noticeable as we age. But is aging destiny or can something different occur over time? 39 Certainly, it is true that arteries are designed for compliance. The Windkessel effect enables 40 energy efficient pulsation of blood from the left ventricle to provide perfusion for the end-users of 41 arterial flow (the tissues and organs of the entire body). The less energy expended with each 42 heartbeat, the better the left ventricle ages and the better perfused these tissues and organs 43 are. Aging stiffens arteries, but exercise can make our arteries relatively younger (than they 44 are) 1, supporting modifiable pathways in aging. However, calcification is an endgame, and 45 calcification of these energy efficient machines (arteries) abrogates the Windkessel effect and 46 changes everything2, 3. In fact, arterial calcification is likely a major driver of mortality in aged 47 persons and those with cardiovascular co-morbidities4. 48Thus, arterial calcification is a very important topic, and this editorial is written to acknowledge 49 an exciting addition to the literature by the exceptionally productive MacTaggart-Kamenskiy 50 laboratory5. Using a large clinical imaging database, the authors describe changes in arterial 51 walls and calcification of these walls as they relate to age in patients from the general area 52 around Omaha, Nebraska. This is an important addition to the literature and a building block to 53 our understanding of one of the most puzzling of all arterial pathologies, arterial calcification6. 54