Probe-hosted silicon photomultipliers for time-domain functional near-infrared spectroscopy: phantom and in vivo tests
Probe-hosted silicon photomultipliers for time-domain functional near-infrared spectroscopy: phantom and in vivo tests
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DOI：
10.1117/1.nph.3.4.045004
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发表时间：
2016-10-01
期刊：
影响因子：
5.3
通讯作者：
Torricelli, Alessandro
中科院分区：
文献类型：
--
作者：
Re, Rebecca;Martinenghi, Edoardo;Torricelli, Alessandro
我们报告了一个紧凑的探头的时域（TD）功能近红外光谱（fNIRS）的基础上快速硅光电倍增管（SiPM），可以直接与样品接触，而不需要光纤的光收集的发展。我们直接在SiPM附近集成了雪崩信号放大级，从而减小了检测通道的尺寸，并优化了信号对电磁干扰的抗扰度。将整个检测电子器件放置在塑料螺钉保持器中，该螺钉保持器与用于脑部测量的脑电图标准帽或与定制探针保持器兼容。将SiPM插入透明绝缘树脂中，以避免头皮与100 V偏置电压直接接触。将探针集成在用于TD fNIRS光谱的仪器中。该系统的特点是在组织幻影的时间分辨率，响应度，线性度和能力，以检测深吸收的变化。对成年志愿者进行了初步的体内试验，以监测袖带闭塞期间手臂和运动任务期间大脑皮层的血液动力学变化。(C)作者。
We report the development of a compact probe for time-domain (TD) functional near-infrared spectroscopy (fNIRS) based on a fast silicon photomultiplier (SiPM) that can be put directly in contact with the sample without the need of optical fibers for light collection. We directly integrated an avalanche signal amplification stage close to the SiPM, thus reducing the size of the detection channel and optimizing the signal immunity to electromagnetic interferences. The whole detection electronics was placed in a plastic screw holder compatible with the electroencephalography standard cap for measurement on brain or with custom probe holders. The SiPM is inserted into a transparent and insulating resin to avoid the direct contact of the scalp with the 100-V bias voltage. The probe was integrated in an instrument for TD fNIRS spectroscopy. The system was characterized on tissue phantoms in terms of temporal resolution, responsivity, linearity, and capability to detect deep absorption changes. Preliminary in vivo tests on adult volunteers were performed to monitor hemodynamic changes in the arm during a cuff occlusion and in the brain cortex during a motor task. (C) The Authors.