Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus
Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus
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DOI：
10.4049/jimmunol.177.2.1349
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发表时间：
2006-07-15
影响因子：
4.4
通讯作者：
Musette, Philippe
中科院分区：
文献类型：
--
作者：
Lartigue, Aurelia;Courville, Philippe;Musette, Philippe
Systemic lupus erythematosus is characterized by the production of autoantibodies directed against nuclear Ags, including nucleosome and DNA. TLR9 is thought to play a role in the production of these autoantibodies through the capacity of nuclear immunogenic particles to interact both with BCR and TLR9. To determine the role of TLR9 in SLE, C57BL/6-lpr/lpr-TLR9(-/-) and TLR9(+/+) mice were analyzed. The abrogation of TLR9 totally impaired the production of anti-nucleosome Abs, whereas no difference was observed in the frequency of anti-dsDNA autoantibodies whose titer was strikingly higher in TLR9(-/-) mice. In addition a higher rate of mesangial proliferation was observed in the kidney of TLR9-deficient animals. These results indicate that in C57BL/6-lpr/lpr mice, TLR9 is absolutely required for the anti-nucleosome Ab response but not for anti-dsDNA Ab production which is involved in mesangial proliferation.
