RECOVERY OF HERPES-SIMPLEX VIRUS FROM HUMAN TRIGEMINAL GANGLIONS
RECOVERY OF HERPES-SIMPLEX VIRUS FROM HUMAN TRIGEMINAL GANGLIONS
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DOI：
10.1056/nejm197303292881303
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发表时间：
1973-01-01
影响因子：
158.5
通讯作者：
SWOVELAND, P
中科院分区：
文献类型：
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作者：
BARINGER, JR;SWOVELAND, P
在7名患者中，有6名患者的三叉神经节中发现了单纯疱疹病毒，这些三叉神经节是在死亡后不到12小时的尸检中获得的，并在培养中保持了10至45天。该病毒不是从同一患者的三叉神经或三叉神经根培养物中获得的。通过荧光抗体和中和试验以及电子显微镜检查，证实了该病毒的身份。结果表明，单纯疱疹病毒在人类三叉神经节中的比例很高，这表明这可能是导致反复口腔感染的潜伏病毒的一个部位。
In six of seven patients, herpes-simplex virus was recovered from trigeminal ganglions obtained at autopsy from unselected cadavers less than 12 hours after death and maintained in culture for 10 to 45 days. The virus was not obtained from similarly handled cultures of trigeminal nerve or root from the same patients. The identity of the virus was confirmed by fluorescent-antibody and neutralization tests and by electron microscopy. The results indicate that herpes-simplex virus is present in a high proportion of human trigeminal ganglions and suggest this as a possible site of latent virus causing recurrent oral infection.