Effects of congenital heart disease on brain development.
Effects of congenital heart disease on brain development.
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DOI：
10.1016/j.ppedcard.2010.06.011
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发表时间：
2010-08-01
影响因子：
0.9
通讯作者：
Licht, Daniel J
中科院分区：
文献类型：
--
作者：
McQuillen, Patrick S;Goff, Donna A;Licht, Daniel J
患有先天性心脏病的胎儿的大脑和心脏发育同时发生。每个器官的早期形态发生程序具有共同的遗传途径。大脑发育发生在一个更长的时间过程中，在妊娠晚期，大脑生长显着，并且依赖于活动的连接形成和完善。这种发育与新陈代谢活动的增加有关，并且大脑依赖心脏来提供氧气和营养物质。先天性心脏病会导致胎儿血流紊乱，从而导致大脑生长和发育受损，这可以通过先进的磁共振成像来测量。发育迟缓导致患有先天性心脏病的新生儿特别容易遭受脑白质损伤。大脑发育迟缓和获得性白质损伤可能是新生儿先天性心脏病手术后儿童常见的轻度但普遍的神经发育障碍的基础。
Brain and heart development occurs simultaneously in the fetus with congenital heart disease. Early morphogenetic programs in each organ share common genetic pathways. Brain development occurs across a more protracted time-course with striking brain growth and activity-dependent formation and refinement of connections in the third trimester. This development is associated with increased metabolic activity and the brain is dependent upon the heart for oxygen and nutrient delivery. Congenital heart disease leads to derangements of fetal blood flow that result in impaired brain growth and development that can be measured with advanced magnetic resonance imaging. Delayed development results in a unique vulnerability to cerebral white matter injury in newborns with congenital heart disease. Delayed brain development and acquired white matter injury may underlay mild but pervasive neurodevelopmental impairment commonly observed in children following neonatal congenital heart surgery.