Parametric imaging of myocardial blood flow with 15O-water and PET using the basis function method.
Parametric imaging of myocardial blood flow with 15O-water and PET using the basis function method.
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发表时间：
2005-07
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通讯作者：
H. Watabe;H. Jino;N. Kawachi;N. Teramoto;Takuya Hayashi;Y. Ohta;H. Iida
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作者：
H. Watabe;H. Jino;N. Kawachi;N. Teramoto;Takuya Hayashi;Y. Ohta;H. Iida
未标记的局部心肌血流量（MBF）可以使用15 O水和PET，使用具有灌注组织分数的1-组织室模型进行测量，该模型提供了不受部分容积效应影响的MBF值。使用15 O-水的研究有几个优点，例如能够重复扫描。然而，由于扫描时间短和心肌中15 O-水的分布体积小，15 O-水的图像质量受到限制，阻碍了体素水平上的MBF和灌注组织分数的计算。我们实现了基函数方法生成参数图像的MBF，灌注组织分数，和动脉血容量（Va）与15 O-水和PET。基函数法线性化的1-组织房室模型，这导致在计算上更快的方法比传统的非线性最小二乘拟合方法估计的参数的解决方案。方法为了验证基函数方法，我们对小型猪（n = 7）进行了一系列PET研究。在采集用于衰减校正的透射扫描和用于获得血池图像的15 O-CO扫描后，用不同剂量的腺苷或CGS-21680（选择性腺苷A（2a）受体激动剂）获得用15 O-水的重复PET扫描。使用基函数法和非线性最小二乘法计算每次扫描的心肌区域的MBF、灌注组织分数和Va值，并比较2种方法估计的参数。结果：用基函数方法生成的MBF图像显示，给予腺苷或CGS-21680后，血流量增加。由基函数法和非线性最小二乘法估计的MBF值相关性很强。结论基函数法可获得15 O水和PET的MBF、灌注组织分数和Va的参数图像。这些图像将有助于检测局部心肌灌注异常。
UNLABELLED Regional myocardial blood flow (MBF) can be measured with 15O-water and PET using the 1-tissue-compartment model with perfusable tissue fraction, which provides an MBF value that is free from the partial-volume effect. Studies with 15O-water have several advantages, such as the ability to repeat a scan. However, because of the short scanning time and the small distribution volume of 15O-water in the myocardium, the image quality of 15O-water is limited, impeding the computation of MBF and perfusable tissue fraction at the voxel level. We implemented the basis function method for generating parametric images of MBF, perfusable tissue fraction, and arterial blood volume (Va) with 15O-water and PET. The basis function method linearizes the solution of the 1-tissue-compartment model, which results in a computationally much faster method than the conventional nonlinear least-squares fitting method in estimating the parameters. METHODS To validate the basis function method, we performed a series of PET studies on miniature pigs (n = 7). After acquisition of the transmission scan for attenuation correction and the 15O-CO scan for obtaining the blood-pool image, repeated PET scans with 15O-water were obtained with varying doses of adenosine or CGS-21680 (selective adenosine A(2a) receptor agonist). MBF, perfusable tissue fraction, and Va values of the myocardial region for each scan were computed using the basis function method and the nonlinear least-squares method, and the parameters estimated by the 2 methods were compared. RESULTS MBF images generated by the basis function method demonstrated an increase in blood flow after administration of adenosine or CGS-21680. The MBF values estimated by the basis function method and by the nonlinear least-squares method correlated strongly. CONCLUSION The basis function method produces parametric images of MBF, perfusable tissue fraction, and Va with 15O-water and PET. These images will be useful in detecting regional myocardial perfusion abnormalities.