Surface-enhanced Raman scattering nanotags for bioimaging
Surface-enhanced Raman scattering nanotags for bioimaging
复制标题
用于生物成像的表面增强拉曼散射纳米标签
DOI：
10.1063/5.0047578
复制
发表时间：
2021-05-21
影响因子：
3.2
通讯作者：
Ye, Jian
中科院分区：
文献类型：
--
作者：
Lin, Li;Bi, Xinyuan;Ye, Jian
表面增强拉曼散射（SERS）技术在生物医学应用中显示出非凡的特性。SERS纳米标签的实施开启了生物成像和检测的新时代。SERS纳米标签作为一种强大的工具，具有指纹谱、峰线宽窄、光稳定性好、空间分辨率高等优点，同时纳米颗粒的设计也很合理。它们已被证明是有效的显像剂，用于体内、体外和体外检测癌细胞和组织。本教程提供了SERS和SERS纳米标签的基本原理，包括基于SERS的生物成像应用的最新进展，以及对临床实际SERS的未来发展的展望。
Surface-enhanced Raman scattering (SERS) technique has shown extraordinary features for biomedical applications. The implementation of SERS nanotags has opened a new era for bioimaging and detections. As a powerful tool, SERS nanotags provide favorable properties such as fingerprint spectrum, narrow peak linewidth, good photostability, and high spatial resolution accompanied by various rational designs of nanoparticles. They have proven as useful imaging agents for in vivo, ex vivo, and in vitro detection of cancerous cells and tissues. This tutorial provides the basic principles of SERS and SERS nanotags, including recent progress of SERS-based bioimaging applications, as well as the outlooks into the future developments toward practical clinical SERS.