Pentamidine analogs: Syntheses, structures in solid state by 13C CP/MAS NMR spectroscopy, and X-ray crystallography and their preliminary biological screening against human cancer
Pentamidine analogs: Syntheses, structures in solid state by 13C CP/MAS NMR spectroscopy, and X-ray crystallography and their preliminary biological screening against human cancer
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DOI：
10.1007/s00706-006-0515-z
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发表时间：
2006-09-01
影响因子：
1.8
通讯作者：
Popis, Sylwia
中科院分区：
文献类型：
--
作者：
Maciejewska, Dorota;Kazmierczak, Pawel;Popis, Sylwia
本文报道了四种新的1，5-双（4-脒基苯氧基）-3-氧杂戊烷类似物的合成。在C-13 CP/MAS NMR谱和DFT水平上的理论计算的基础上，在固态下评估所获得的双脒和双腈的结构。本文报道了1，5-双（4-脒基苯氧基）-3-氧杂戊烷的单晶X-射线衍射结构。还给出了对三种细胞系的初步抗癌测定。
The synthesis of four new 1,5-bis(4-amidinophenoxy)-3-oxapentane analogs is described. The structures of the obtained bis-amidines and bis-nitriles in the solid state are evaluated on the basis of C-13 CP/MAS NMR spectra and theoretical calculations at DFT level. A single crystal X-ray diffraction structure is presented for 1,5-bis(4-amidinophenoxy)-3-oxapentane. A preliminary anticancer assay against three cell lines is also given.