Synthesis of a thioester linker precursor for a general preparation of peptide C-terminal thioacids
Synthesis of a thioester linker precursor for a general preparation of peptide C-terminal thioacids
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DOI：
10.1016/j.tetlet.2003.12.160
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发表时间：
2004-03-01
影响因子：
1.8
通讯作者：
Canne, L
中科院分区：
文献类型：
--
作者：
Gaertner, H;Villain, M;Canne, L
介绍了固相法合成多肽硫代酸的一般工艺。该方法包括合成作为总前体的4-[alpha-(S-acetyl)mercaptobenzyl]phenoxyacetic酸。该试剂一旦连接到固体载体上，在去保护硫醇后用所选择的BOC-氨基酸进行衍生化。(C)2004爱思唯尔有限公司。保留所有权利。
A general procedure to prepare peptide thioacids by solid-phase peptide synthesis is presented. The method involves the synthesis of 4-[alpha-(S-acetyl)mercaptobenzyl]phenoxyacetic acid as general precursor. This reagent once attached to a solid support is derivatized with the Boc-amino acid of choice after deprotection of the thiol. (C) 2004 Elsevier Ltd. All rights reserved.