EFFECTS OF THE HYPOGLYCEMIC DRUGS REPAGLINIDE AND GLIBENCLAMIDE ON ATP-SENSITIVE POTASSIUM-CHANNELS AND CYTOSOLIC CALCIUM LEVELS IN BETA-TC3 CELLS AND RAT PANCREATIC BETA-CELLS
EFFECTS OF THE HYPOGLYCEMIC DRUGS REPAGLINIDE AND GLIBENCLAMIDE ON ATP-SENSITIVE POTASSIUM-CHANNELS AND CYTOSOLIC CALCIUM LEVELS IN BETA-TC3 CELLS AND RAT PANCREATIC BETA-CELLS
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DOI：
10.1007/bf00402171
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发表时间：
1995-09-01
期刊：
影响因子：
8.2
通讯作者：
FROKJAERJENSEN, J
中科院分区：
文献类型：
--
作者：
GROMADA, J;DISSING, S;FROKJAERJENSEN, J
本研究证明了降糖药物瑞格列奈和格列本脲在培养的新生大鼠胰岛细胞和小鼠β TC 3细胞中的作用。在短期实验中，在新生大鼠胰岛细胞的细胞贴附膜贴片中，瑞格列奈（10 nmol/l）和格列本脲（20 nmol/l）将单个ATP敏感性K+通道的开放概率降低至加入药物前活性的约10%（
The present study demonstrates the action of the hypoglycaemic drugs repaglinide and glibenclamide in cultured newborn rat islet cells and mouse beta TC3 cells. In cell-attached membrane patches of newborn rat islet cells repaglinide (10 nmol/l) and glibenclamide (20 nmol/l) decrease the open probability of single ATP-sensitive K+-channels to approximately 10 % of the activity prior to addition of the drugs in short-term experiments (