Bacteraemia in malnourished rural African children
Bacteraemia in malnourished rural African children
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DOI：
10.1080/02724936.1996.11747805
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发表时间：
1996-03-01
影响因子：
--
通讯作者：
Rothberg, AD
中科院分区：
文献类型：
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作者：
Reed, RP;Wegerhoff, FO;Rothberg, AD
在为期5个月的研究期间，南非农村Shongwe使命医院收治的863名5岁以下儿童中有323名（37.5%）营养不良，其中三分之二严重营养不良。营养不良儿童菌血症发生率为9.6%，严重营养不良儿童菌血症发生率为11.8%，营养性侏儒儿童菌血症发生率为5.8%。回收的主要微生物为革兰氏阴性肠杆菌（48.5%）。在严重营养不良者中，经验性地接受静脉注射氨苄青霉素和庆大霉素，95.8%的所有分离株对这种抗生素组合敏感。严重营养不良菌血症患儿病死率为20.8%。在营养不良的总体分类中，菌血症儿童的病死率（22.6%）明显高于无菌血症儿童（9.3%）。在资源有限的医院，可能不需要全面鉴定细菌，只要定期监测新出现的耐药性。
During a 5-month study period, 323 of 863 (37.5%) children below 5 years of age admitted to Shongwe Mission Hospital in rural South Africa were malnourished, two-thirds severely so. The incidence of bacteraemia in malnourished children was 9.6%, 11.8% in those severely malnourished and 5.8% in nutritional dwarfs. The predominant organisms retrieved were Gram-negative enteric bacilli (48.5%). Amongst the severely malnourished, who empirically receive intravenous ampicillin and gentamicin, 95.8% of all isolates were sensitive to this antibiotic combination. The case fatality rate of severely malnourished bacteraemic children was 20.8%. In malnutrition categories overall, the case fatality rate for bacteraemic children (22.6%) was significantly greater than in those without bacteraemia (9.3%). In hospitals with limited resources, full identification of bacteria may not be necessary, provided that regular surveillance for emerging resistance is conducted.