Measurement of blood flow to the ventral prostate in the rat with radioactive microspheres: effects of estradiol-17 beta and human chorionic gonadotrophin.
Measurement of blood flow to the ventral prostate in the rat with radioactive microspheres: effects of estradiol-17 beta and human chorionic gonadotrophin.
复制标题
用放射性微球测量大鼠腹侧前列腺的血流量：雌二醇 17β 和人绒毛膜促性腺激素的作用。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
J. Damber
中科院分区：
文献类型：
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作者：
G. Selstam;J. Damber
大鼠腹侧前列腺的功能和大小受雄激素的刺激和雌激素的抑制。为了测试前列腺中的血流是否以类似的方式受到影响，在给予人绒毛膜促性腺激素（hCG）后，在有和没有雌二醇-17 β（E2）预处理的大鼠中以及在有和没有E2处理的去势5天的大鼠中测量前列腺血流。用微球技术测量前列腺血流量，该技术允许在不干扰器官的情况下测量血流量。E2治疗导致完整和去势大鼠前列腺血流量减少，hCG注射后，血流量恢复正常。得出的结论是，E2诱导的前列腺血流量的减少至少部分介导的直接作用于前列腺。
The function and size of the rat ventral prostate are stimulated by androgens and inhibited by estrogens. In order to test whether the blood flow in prostate is influenced in a similar fashion prostatic blood flow was measured after administration of human chorionic gonadotrophin (hCG) in rats with and without pretreatment of estradiol-17 beta (E2) and in rats castrated for five days with and without treatment with E2. Prostatic blood flow was measured with the microsphere technique, which allows blood flow measurement without any interference with the organ. E2 treatment resulted in a decreased prostatic blood flow in both intact and castrated rats, and blood flow was restored to normal in intact rats after hCG-injection. It was concluded that the E2 induced decrement of prostatic blood flow was at least in part mediated by a direct effect on the prostate.