miRNAs in cancer prevention and treatment and as molecular targets for natural product anticancer agents.
miRNAs in cancer prevention and treatment and as molecular targets for natural product anticancer agents.
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DOI：
10.2174/15680096113139990031
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发表时间：
2013-05
影响因子：
3
通讯作者：
B. Qian;S. Nag;Yu-liang Su;Sukesh Voruganti;Jiangjiang Qin;Ruiwen Zhang;W. Cho
中科院分区：
文献类型：
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作者：
B. Qian;S. Nag;Yu-liang Su;Sukesh Voruganti;Jiangjiang Qin;Ruiwen Zhang;W. Cho
microRNA（miRNAs）是一种内源性小分子非编码RNA，通过与靶mRNA的3 ′端非翻译区结合来调节基因表达，通过mRNA降解或翻译抑制导致转录后基因沉默。miRNAs参与许多生物学过程，包括致癌作用。它们可以作为癌基因或肿瘤抑制基因，其异常表达与肿瘤的发生和发展密切相关。因此，miRNAs已被用作肿瘤诊断、预后以及肿瘤治疗靶点的潜在生物标志物。最近，已经证明饮食和天然化学预防剂通过调节一种或多种miRNA发挥其抗癌活性。除了阐述miRNAs在癌症中的最新发现外，本文还讨论了miRNAs的翻译研究，重点是天然产物在癌症治疗中的作用。
MicroRNAs (miRNAs) are endogenous small non-coding RNAs that regulate gene expression by binding to the 3´untranslated region of target mRNA, resulting in posttranscriptional gene silencing via mRNA degradation or translation inhibition. miRNAs are involved in many biological processes including carcinogenesis. They can act as oncogenes or tumor suppressors and their aberrant expressions are intimately linked with cancer development and progression. Therefore, miRNAs have been utilized as potential biomarkers for cancer diagnosis, prognosis, as well as cancer therapeutic targets. Recently, it has been demonstrated that dietary and natural chemopreventive agents exert their anticancer activities through the regulation of one or more miRNAs. In addition to expounding the latest findings of miRNAs in cancer, this review also discusses the recent efforts on the translational research of miRNAs, with an emphasis on natural products in the treatment of cancer.