Genetic and Environmental Contributions to Associations between Infant Fussy Temperament and Antisocial Behavior in Childhood and Adolescence.
Genetic and Environmental Contributions to Associations between Infant Fussy Temperament and Antisocial Behavior in Childhood and Adolescence.
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DOI：
10.1007/s10519-016-9794-2
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发表时间：
2016-09
影响因子：
2.6
通讯作者：
D'Onofrio BM
中科院分区：
文献类型：
--
作者：
Goodnight JA;Donahue KL;Waldman ID;Van Hulle CA;Rathouz PJ;Lahey BB;D'Onofrio BM
先前的研究表明，婴儿期的挑剔气质预示着儿童和青少年后期反社会行为（ASB）的风险。然而，目前尚不清楚婴儿的烦躁在多大程度上与后来的ASB通过因果过程相关，或者它们是否都反映了ASB的相同家庭危险因素。目前的研究使用了两种方法，兄弟姐妹的比较和双变量生物特征建模，以减少家族混杂，并检查遗传和环境对儿童期和青春期后期的前两年的烦躁与ASB之间的关联的影响。对来自一个前瞻性队列的数据进行了分析（4-9岁的9，237人和14- 17岁的7，034人），他们是美国妇女全国代表性样本的后代。在完整的样本中，大惊小怪预测儿童和青少年ASB小，但显着的程度，控制了广泛的测量儿童和家庭层面的协变量。当比较不同的兄弟姐妹在他们的烦躁不安，烦躁不安预测ASB在儿童时期，但不是ASB在青春期。此外，从一个双变量Cholesky模型的结果表明，即使是与儿童ASB比较兄弟姐妹时发现的烦躁的关联可归因于家庭因素。也就是说，虽然家庭的婴儿谁是更高的烦躁也往往有儿童和青少年谁从事更大的ASB，假设婴儿烦躁有一个环境介导的影响，未来ASB的发展没有得到有力的支持。
Previous research suggests that fussy temperament in infancy predicts risk for later antisocial behavior (ASB) in childhood and adolescence. It remains unclear, however, to what extent infant fussiness is related to later ASB through causal processes or if they both reflect the same family risk factors for ASB. The current study used two approaches, the comparison of siblings and bivariate biometric modeling, to reduce familial confounding and examine genetic and environmental influences on associations between fussiness in the first two years of life and ASB in childhood and late adolescence. Analyses were conducted on data from a prospective cohort (9,237 at 4-9 years and 7,034 at 14-17years) who are the offspring of a nationally representative sample of U.S. women. In the full sample, fussiness predicted both child and adolescent ASB to small but significant extents, controlling for a wide range of measured child and family-level covariates. When siblings who differed in their fussiness were compared, fussiness predicted ASB in childhood, but not ASB during adolescence. Furthermore, results from a bivariate Cholesky model suggested that even the association of fussiness with childhood ASB found when comparing siblings is attributable to familial factors. That is, although families with infants who are higher in fussiness also tend to have children and adolescents who engage in greater ASB, the hypothesis that infant fussiness has an environmentally mediated impact on the development of future ASB was not strongly supported.