Balancing sensitivity, risk, and immunopathology in immune regulation.
Balancing sensitivity, risk, and immunopathology in immune regulation.
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DOI：
10.1016/j.cois.2022.100874
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发表时间：
2022-04
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
--
作者：
免疫反应的激活在能量上是昂贵的，过度的免疫系统活动可能导致免疫病理，然而缓慢或不充分的免疫反应会带来病原体建立的风险，从而导致感染引起的病理。数学理论和经验数据表明，宿主通过密切调节免疫动力学来平衡免疫成本和感染风险。一个最佳的免疫系统能够迅速而有力地部署，以对抗真正的感染威胁，一旦威胁得到控制，它就会迅速失效。免疫系统敏感性的遗传变异，以及宿主免疫反应的激活和关闭动力学，可以促进病原体毒力的进化和宿主对感染的耐受性。提高对免疫调节动力学上的适应性力量的理解将阐明控制先天免疫系统进化和维持的基本原理。
Activation of an immune response is energetically costly and excessive immune system activity can result in immunopathology, yet a slow or insufficient immune response carries the risk of pathogen establishment with consequent pathology arising from the infection. Mathematical theory and empirical data demonstrate that hosts balance the costs of immunity against the risk of infection by closely regulating immunological dynamics. An optimal immune system is rapidly and robustly deployed against a true infectious threat and rapidly deactivated once the threat has been controlled. Genetic variation in the sensitivity of an immune system, as well as in the activation and shutdown kinetics of host immune responses, can contribute to the evolution of pathogen virulence and host tolerance of infection. Improved understanding of the adaptive forces that operate on immune regulatory dynamics will clarify fundamental principles governing the evolution and maintenance of innate immune systems.
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影响因子：
9.8
作者：
Bajgar A;Kucerova K;Jonatova L;Tomcala A;Schneedorferova I;Okrouhlik J;Dolezal T
通讯作者：
Dolezal T
影响因子：
16
作者：
Issa N;Guillaumot N;Lauret E;Matt N;Schaeffer-Reiss C;Van Dorsselaer A;Reichhart JM;Veillard F
通讯作者：
Veillard F
影响因子：
3.4
作者：
Howick VM;Lazzaro BP
通讯作者：
Lazzaro BP
影响因子：
3.3
作者：
Ayres, Janelle S.;Freitag, Nancy;Schneider, David S.
通讯作者：
Schneider, David S.
影响因子：
4.9
作者：
Howick, Virginia M.;Lazzaro, Brian P.
通讯作者：
Lazzaro, Brian P.