Distinct cortical-amygdala projections drive reward value encoding and retrieval
Distinct cortical-amygdala projections drive reward value encoding and retrieval
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DOI：
10.1038/s41593-019-0374-7
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发表时间：
2019-05-01
影响因子：
25
通讯作者：
Wassum, Kate M.
中科院分区：
文献类型：
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作者：
Malvaez, Melissa;Shieh, Christine;Wassum, Kate M.
预期回报事件的价值是决定是否参与其追求的关键组成部分。但是，人们对负责编码和检索这些值的网络知之甚少。通过使用生物传感器和药理学操作，我们发现，基底外侧杏仁核（BLA）神经元活动的跟踪和介导的编码和检索的状态依赖的奖励价值的美味的食物奖励。投射特异性、双向化学遗传学和光遗传学操作显示，眶额皮质（OFC）在这些过程中支持BLA。重要的是，腹外侧和内侧OFC -> BLA投射的功能是双重分离的。外侧OFC -> BLA投射对于编码奖励的正值是必要且充分的，而内侧OFC -> BLA投射对于从记忆中检索该值是必要且充分的。这些数据揭示了适应性奖励评估和追求的新回路，并提供了对这些过程中功能障碍的深入了解，这些功能障碍是无数精神疾病的特征。
The value of an anticipated rewarding event is a crucial component of the decision to engage in its pursuit. But little is known of the networks responsible for encoding and retrieving this value. By using biosensors and pharmacological manipulations, we found that basolateral amygdala (BLA) glutamatergic activity tracks and mediates encoding and retrieval of the state-dependent incentive value of a palatable food reward. Projection-specific, bidirectional chemogenetic and optogenetic manipulations revealed that the orbitofrontal cortex (OFC) supports the BLA in these processes. Critically, the function of ventrolateral and medial OFC -> BLA projections is doubly dissociable. Whereas lateral OFC -> BLA projections are necessary and sufficient for encoding of the positive value of a reward, medial OFC -> BLA projections are necessary and sufficient for retrieving this value from memory. These data reveal a new circuit for adaptive reward valuation and pursuit and provide insight into the dysfunction in these processes that characterizes myriad psychiatric diseases.