Electrical impedance spectroscopy of the breast: Clinical imaging results in 26 subjects
Electrical impedance spectroscopy of the breast: Clinical imaging results in 26 subjects
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DOI：
10.1109/tmi.2002.800606
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发表时间：
2002-06-01
影响因子：
10.6
通讯作者：
Poplack, SP
中科院分区：
文献类型：
--
作者：
Kerner, TE;Paulsen, KD;Poplack, SP
电阻抗谱（EIS）是一种潜在的，非侵入性的技术，以图像妇女乳腺癌。研究表明，恶性肿瘤与正常组织的电导率和介电常数存在特征频率分散。使用多频EIS系统，我们成像的乳房26名妇女。所有患者的乳房X线照片均使用美国放射学会（ACR）BIRADS系统进行排名。在51个单独的乳房成像中，38个为ACR I阴性，6个为ACR 4 - 5可疑病变，7个为不良ACR 2良性病变，如纤维腺瘤或钙化。当患者俯卧时，将16个Ag/AgCl电极的径向可平移圆形阵列放置在乳房周围。我们在10和950 kHz之间的10个频率下应用三角电压模式。使用非线性偏微分方程方法从这些数据重建解剖冠状图像。通常，ACR I级乳房在单个中心平面中进行询问，而ACR 2 - 5级乳房在覆盖可疑区域的多个平面中进行成像。一般而言，乳腺摄影正常病例出现特征性均匀图像，而恶性肿瘤妇女的图像中观察到局灶性不均匀。使用特定的视觉标准，EIS图像识别了83%的ACR 4 - 5病变，而使用数字标准检测到67%。总的来说，多频电阻抗成像似乎有希望检测乳腺恶性肿瘤，但必须作出改进之前，该方法达到其全部潜力。
Electrical impedance spectroscopy (EIS) is a potential, noninvasive technique to image women for breast cancer. Studies have shown characteristic frequency dispersions in the electrical conductivity and permittivity of malignant versus normal tissue. Using a multifrequency EIS system, we imaged the breasts of 26 women. All patients had mammograms ranked using the American College of Radiology (ACR) BIRADS system. Of the 51 individual breasts imaged, 38 were ACR I negative, six had ACR 4-5 suspicious lesions, and seven bad ACR 2 benign findings such as fibroadenomas or calcifications. A radially translatable circular array of 16 Ag/AgCl electrodes was placed around the breast while the patient lay prone. We applied trigonometric voltage patterns at ten frequencies between 10 and 950 kHz. Anatomically coronal images were reconstructed from this data using nonlinear partial differential equation methods. Typically, ACR I-rated breasts were interrogated in a single central plane whereas ACR 2-5-rated breasts were imaged in multiple planes covering the region of suspicion. In general, a characteristic homogeneous image emerged for mammographically normal cases while focal inhomogeneities were observed in images from women with malignancies. Using a specific visual criterion, EIS images identified 83% of the ACR 4-5 lesions while 67% were detected using a numerical criterion. Overall, multifrequency electrical impedance imaging appears promising for detecting breast malignancies, but improvements must be made before the method reaches its full potential.