Continuous Effect of Radial Resection Margin on Recurrence and Survival in Rectal Cancer Patients Who Receive Preoperative Chemoradiation and Curative Surgery: A Multicenter Retrospective Analysis
Continuous Effect of Radial Resection Margin on Recurrence and Survival in Rectal Cancer Patients Who Receive Preoperative Chemoradiation and Curative Surgery: A Multicenter Retrospective Analysis
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DOI：
10.1016/j.ijrobp.2017.03.008
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发表时间：
2017-07-01
影响因子：
7
通讯作者：
Lee, Jong Hoon
中科院分区：
文献类型：
--
作者：
Sung, SooYoon;Kim, Sung Hwan;Lee, Jong Hoon
目的：目的：探讨直肠癌术前放化疗（CRT）后行根治性全直肠系膜切除术（TME.Methods and Materials）的切缘长度及预后价值。方法：对1476例cT 3 - 4 N 0 - 2 M0期直肠癌患者进行分析。所有患者均接受28次50.4戈伊的放疗，同时接受5-氟尿嘧啶或卡培他滨。放疗后4 ~ 8周行全直肠系膜切除术。结果：3组患者5年无复发生存率（RFS）差异有统计学意义：环周切除缘（CRM）5 mm的患者（46.2% vs 68.6% vs 77.5%，P
Purpose: To elucidate the proper length and prognostic value of resection margins in rectal cancer patients who received preoperative chemoradiotherapy (CRT) followed by curative total mesorectal excision (TME).Methods and Materials: A total of 1476 rectal cancer patients staging cT3-4N0-2M0 were analyzed. All patients received radiation dose of 50.4 Gy in 28 fractions with concurrent 5-fluorouracil or capecitabine. Total mesorectal excision was performed 4 to 8 weeks after radiation therapy.Results: The recurrence-free survival (RFS) at 5 years showed a significant difference between 3 groups: patients with circumferential resection margin (CRM) 5 mm (46.2% vs 68.6% vs 77.5%, P