Cell and Molecular Biology
Cell and Molecular Biology
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DOI：
10.1007/978-3-540-76735-0_8
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
P. Russell
中科院分区：
文献类型：
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作者：
P. Russell
真正的放射性示踪剂或分子成像探针最重要的特征之一是能够在不干扰其功能的情况下研究稳态系统的组成部分。了解细胞和分子生物学的基础知识是设计靶向分子成像探针必不可少的。因此，本章提供了一个广泛的概述，包括细胞结构和功能，细胞繁殖和细胞周期，细胞转化和分化，细胞信号传导和膜受体，细胞和膜运输机制，最后是细胞代谢的各个部分。简要总结了遗传密码、DNA转录和DNA翻译导致蛋白质合成的基础知识。由于分子成像的目标是成像与不同疾病的病理生理学相关的改变，疾病的定义，改变的细胞和组织和生物学，最后细胞损伤及其后果也在最后简要讨论。
One of the most important characteristics of a true radiotracer or a molecular imaging probe is the ability to study the components of a homeostatic system with out disturbing its function. Understanding the basics of cell and molecular biology is essential in the design of targeted molecular imaging probes. Therefore, this chapter provides a broad overview and includes various sections on cell structure and function, the cell reproduction and cell cycle, cell transformation and differentiation, cell signaling and membrane receptors, cell and membrane transport mechanisms and finally cellular metabolism. The basics of genetic code, DNA transcription, and DNA translation leading to protein synthesis are briefly summarized. Since the goal of molecular imaging is to image the alterations associated with the pathophysiology of different diseases, the definition of disease, altered cellular and tissue and biology, and finally cellular injury its consequences are also briefly discussed at the end.