C-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort
C-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort
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DOI：
10.1038/jhh.2010.125
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发表时间：
2012-02-01
影响因子：
2.7
通讯作者：
Lam, K. S. L.
中科院分区：
文献类型：
--
作者：
Cheung, B. M. Y.;Ong, K. L.;Lam, K. S. L.
炎症有助于高血压的发展。C-反应蛋白（CRP）是否在高血压中起因果作用仍不清楚。我们研究了循环CRP水平与高血压的关系。研究CRP基因单核苷酸多态性（SNPs）作为其血浆水平和高血压倾向的决定因素的作用。从2000-2004年的香港心血管危险因素流行病学研究-2（CRISPS-2）中，对1925名无关受试者的血浆CRP和9个SNP的基因型进行了测定。在CRISPS-2中的1378名血压正常的受试者中，1115名受试者在中位间隔5.3年后在CRISPS-3中接受了随访，其中236名受试者发生了高血压。在CRISPS-3中，血浆CRP与高血压的发生独立相关（每四分位数比值比1.26，P = 0.010）。6个SNP与血浆CRP相关（均P
Inflammation contributes to the development of hypertension. Whether C-reactive protein (CRP) has a causal role in hypertension remains unknown. We studied the relationship between circulating CRP levels and hypertension. The role of single-nucleotide polymorphisms (SNPs) in the CRP gene as determinants of its plasma levels and the propensity to develop hypertension was investigated. Plasma CRP and genotypes of nine SNPs were determined in 1925 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000-2004. Among 1378 subjects normotensive in CRISPS-2, 1115 subjects had been followed up in CRISPS-3 after a median interval of 5.3 years, 236 of whom had developed hypertension. Plasma CRP was independently associated with the development of hypertension in CRISPS-3 (odds ratio per quartile 1.26, P = 0.010). Six SNPs were associated with plasma CRP (all P