Effects of antipsychotics and amphetamine on social behaviors in spontaneously hypertensive rats
Effects of antipsychotics and amphetamine on social behaviors in spontaneously hypertensive rats
复制标题
DOI：
10.1016/j.bbr.2011.06.026
复制
发表时间：
2011-11-20
影响因子：
2.7
通讯作者：
Abilio, Vanessa Costhek
中科院分区：
文献类型：
--
作者：
Calzavara, Mariana Bendlin;Levin, Raquel;Abilio, Vanessa Costhek
我们最近报道，自发性高血压大鼠（SHR）表现出的背景下的恐惧条件反射，这是专门逆转抗精神病药和增强精神兴奋剂和其他操作被认为是产生精神分裂症样的状态在啮齿动物的赤字。基于这些发现，我们认为这种恐惧条件反射的缺陷可以作为精神分裂症中观察到的情绪处理障碍的实验模型。这种菌株也被建议作为研究注意力缺陷/多动障碍（ADHD）的模型。考虑到精神分裂症和ADHD都具有社会功能低下的特点，本研究旨在探讨SHR在社会背景下可能存在的行为缺陷。此外，我们试图检查典型和非典型抗精神病药物（用于治疗精神分裂症）和精神兴奋剂（用于治疗ADHD）对这些行为的影响。成对的相同或不同的不熟悉的大鼠（即，Wistar）品系用上述药物之一处理，并放置在开放场中10 min。在此期间，对社会行为、运动和饲养频率进行评分。非典型抗精神病药物增加了Wistar大鼠（WR）的社会互动，并改善了SHR表现出的社会互动缺陷。此外，SHR组表现出过度运动，所有抗精神病药物（奎替鲁和氯氮平也减少了WR的运动）和增强安非他明（这也增加了WR的运动）衰减。我们的研究结果表明，SHR组的行为特征表明，这种菌株可以是一个有用的动物模型，研究精神分裂症的几个方面。(C)2011爱思唯尔有限公司版权所有。
We have recently reported that spontaneously hypertensive rats (SHRs) exhibit a deficit in contextual fear conditioning that is specifically reversed by antipsychotic and potentiated by psychostimulants and other manipulations thought to produce schizophrenia-like states in rodents. Based on these findings, we suggested that this deficit in fear conditioning could be used as an experimental model of emotional processing impairments observed in schizophrenia. This strain has also been suggested as a model by which to study attention deficit/hyperactivity disorder (ADHD). Considering that schizophrenia and ADHD are both characterized by poor social function, this study aimed to investigate possible behavioral deficits of SHRs in a social context. Furthermore, we sought to examine the effects of typical and atypical antipsychotics (used for the treatment of schizophrenia) and a psychostimulant (used to treat ADHD) on these behaviors. Pairs of unfamiliar rats of the same or different (i.e., Wistar) strains were treated with one of the aforementioned drugs and placed in an open-field for 10 min. During this time, social behaviors, locomotion and rearing frequencies were scored. Atypical antipsychotics increased social interaction in Wistar rats (WRs) and improved the deficit in social interaction exhibited by SHRs. In addition, the SHR group displayed hyperlocomotion that was attenuated by all antipsychotics (quetiapine and clozapine also decreased locomotion in WRs) and potentiated by amphetamine (which also increased locomotion in WRs). Our results reveal that the behavioral profile of the SHR group demonstrates that this strain can be a useful animal model to study several aspects of schizophrenia. (C) 2011 Elsevier B.V. All rights reserved.