Reinstatement of nicotine-conditioned place preference by drug priming: Effects of calcium channel antagonists
Reinstatement of nicotine-conditioned place preference by drug priming: Effects of calcium channel antagonists
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DOI：
10.1016/j.ejphar.2006.03.017
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发表时间：
2006-05-10
影响因子：
5
通讯作者：
Budzynska, Barbara
中科院分区：
文献类型：
--
作者：
Biala, Grazyna;Budzynska, Barbara
在动物中恢复药物寻求行为与人类的药物复吸有关。本研究采用条件性位置偏爱实验范式，探讨尼古丁诱导的大鼠位置条件化的建立、消退、恢复和交叉恢复过程。尼古丁产生了对最初不太优选的隔室的位置偏好，在调节期间与其注射配对（0.5 mg/kg，i. p.，三次药物治疗）。一旦建立，尼古丁位置偏好被反复训练所消除。在这个消退阶段之后，研究了位置调节的恢复。为此目的，将经历尼古丁的大鼠用尼古丁（0.5 mg/kg，i. p.）或吗啡（10 mg/kg，i. p.）。这两种药物的引发注射重新显示了对先前与尼古丁配对的隔室的明显偏好。在第二步中，我们检查了钙通道拮抗剂尼莫地平（10和20 mg/kg，i. p.）和氟桂利嗪（5和10 mg/kg，i. p.），尼古丁和吗啡引发剂量诱发的尼古丁条件性位置偏爱的恢复。结果表明，钙通道阻滞剂剂量依赖性地减弱了两种药物诱导的尼古丁位置偏爱的恢复。这些研究结果支持了这一假设，即尼古丁和吗啡诱导的复吸中涉及类似的神经钙依赖机制。最后，条件性位置偏好范式似乎是一个有用的工具，在实验室动物的药物寻求行为的复发研究。(c)2006 Elsevier B. V.保留所有权利。
Reinstatement of drug-seeking behaviour in animals is relevant to drug relapse in humans. In the present study, we used the conditioned place preference paradigm to investigate the establishment, extinction, reinstatement and cross-reinstatement of nicotine-induced place conditioning in rats. Nicotine produced a place preference to the initially less-preferred compartment paired with its injections during conditioning (0.5 mg/kg, i.p., three drug sessions). Once established, nicotine place preference was extinguished by repeated training. Following this extinction phase, the reinstatement of place conditioning was investigated. For this purpose, nicotine-experienced rats were challenged with nicotine (0.5 mg/kg, i.p.) or morphine (10 mg/kg, i.p.). These priming injections of both drugs renewed a marked preference for the compartment previously paired with nicotine. In the second step, we examined the influence of the calcium channel antagonists, nimodipine (10 and 20 mg/kg, i.p.) and flunarizine (5 and 10 mg/kg, i.p.), on the reinstatement of nicotine-conditioned place preference induced by priming doses of nicotine and morphine. It was shown that the calcium channel blockers dose dependently attenuated the reinstatement of nicotine place preference induced by both drugs. These findings support the hypothesis that similar neural calcium-dependent mechanisms are involved in nicotine- and morphine-induced reinstatement. Finally, the conditioned place preference paradigm appears to be a useful tool for studies of the relapse of drug-seeking behaviour in laboratory animals. (c) 2006 Elsevier B.V. All rights reserved.