Metabolic Modulation in Macrophage Effector Function.
Metabolic Modulation in Macrophage Effector Function.
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DOI：
10.3389/fimmu.2018.00270
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发表时间：
2018
影响因子：
7.3
通讯作者：
Pålsson-McDermott EM
中科院分区：
文献类型：
--
作者：
Diskin C;Pålsson-McDermott EM
传统上，细胞呼吸或代谢被视为分解代谢和合成代谢途径，产生生长和一般细胞维持所需的能量和生物合成前体。然而，越来越多的文献提供了代谢反应和过程在控制免疫效应功能中更广泛作用的证据。大部分关于免疫代谢的研究都集中在巨噬细胞上，巨噬细胞是促炎和抗炎反应的中心细胞，而这些反应又是代谢重编程的直接结果。随着我们更多地了解代谢途径和途径中间体在免疫功能中的精确作用，一个以免疫代谢为治疗目标的新机会出现了。在这里，我们回顾了目前的理解，通过代谢重塑的巨噬细胞功能的调节。
Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic pathways generating energy and biosynthetic precursors required for growth and general cellular maintenance. However, growing literature provides evidence of a much broader role for metabolic reactions and processes in controlling immunological effector functions. Much of this research into immunometabolism has focused on macrophages, cells that are central in pro- as well as anti-inflammatory responses—responses that in turn are a direct result of metabolic reprogramming. As we learn more about the precise role of metabolic pathways and pathway intermediates in immune function, a novel opportunity to target immunometabolism therapeutically has emerged. Here, we review the current understanding of the regulation of macrophage function through metabolic remodeling.
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影响因子：
64.5
作者：
Chang CH;Curtis JD;Maggi LB Jr;Faubert B;Villarino AV;O'Sullivan D;Huang SC;van der Windt GJ;Blagih J;Qiu J;Weber JD;Pearce EJ;Jones RG;Pearce EL
通讯作者：
Pearce EL
影响因子：
64.8
作者：
CURRIE, GA
通讯作者：
CURRIE, GA
影响因子：
5.3
作者：
Arif, Abul;Chatterjee, Piyali;Fox, Paul L.
通讯作者：
Fox, Paul L.
影响因子：
30.5
作者：
Cader MZ;Boroviak K;Zhang Q;Assadi G;Kempster SL;Sewell GW;Saveljeva S;Ashcroft JW;Clare S;Mukhopadhyay S;Brown KP;Tschurtschenthaler M;Raine T;Doe B;Chilvers ER;Griffin JL;Kaneider NC;Floto RA;D'Amato M;Bradley A;Wakelam MJ;Dougan G;Kaser A
通讯作者：
Kaser A
DOI：
10.1084/jem.20102049
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bulua AC;Simon A;Maddipati R;Pelletier M;Park H;Kim KY;Sack MN;Kastner DL;Siegel RM
通讯作者：
Siegel RM