Triggered Nanoparticles as Therapeutics.
Triggered Nanoparticles as Therapeutics.
复制标题
DOI：
10.1016/j.nantod.2013.07.004
复制
发表时间：
2013-08-01
期刊：
影响因子：
17.4
通讯作者：
Rotello VM
中科院分区：
文献类型：
--
作者：
Kim CS;Duncan B;Creran B;Rotello VM
药物输送系统 (DDS) 面临多项挑战，包括特定位点输送、稳定性和药物的程序化释放。具有响应部分的工程纳米颗粒 (NP) 表面可以增强 DDS 在体外和体内系统中的功效。该触发过程可以通过内源性（生物控制释放）和外源性（外部刺激控制释放）激活来实现。在这篇综述中，我们将重点介绍最近在体外和体内应用工程纳米材料触发释放策略的例子。
Drug delivery systems (DDSs) face several challenges including site-specific delivery, stability, and the programmed release of drugs. Engineered nanoparticle (NP) surfaces with responsive moieties can enhance the efficacy of DDSs for in vitro and in vivo systems. This triggering process can be achieved through both endogenous (biologically controlled release) and exogenous (external stimuli controlled release) activation. In this review, we will highlight recent examples of the use of triggered release strategies of engineered nanomaterials for in vitro and in vivo applications.