Optimal vaccination policies for stochastic epidemics among a population of households
Optimal vaccination policies for stochastic epidemics among a population of households
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DOI：
10.1016/s0025-5564(01)00095-5
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发表时间：
2002-05-01
影响因子：
4.3
通讯作者：
Lyne, OD
中科院分区：
文献类型：
--
作者：
Ball, FG;Lyne, OD
本文考虑以家庭为单位的人口中的随机流行病，其中家庭内部的局部混合和整个人口的全局混合。这两种混合水平对流行病的阈值行为具有重要影响，因此对最佳疫苗接种政策的形成和构建具有重要影响。最优性是根据疫苗接种规划的费用来考虑的，其形式一般足以包括疫苗本身、疫苗管理、前往和/或与家庭接触的费用。通过一种解释最优疫苗接种政策形式的构造方法获得了新的明确结果。最后给出了数值研究，以验证所讨论的结果。(C) 2002爱思唯尔科学有限公司版权所有。
This paper considers stochastic epidemics among a population partitioned into households, with mixing locally within households and globally throughout the population. The two levels of mixing have important implications for the threshold behaviour of the epidemic and consequently for the form and construction of optimal vaccination policies. Optimality is considered in terms of the cost of the vaccination program, the form of which is general enough to include costs of the vaccine itself, its administration, travel to and/or contact with the households. New explicit results are obtained by a constructive method which explain the form of optimal vaccination policies. Numerical studies are presented which exemplify the results discussed. (C) 2002 Elsevier Science Inc. All rights reserved.