Motion Control of Urea-Powered Biocompatible Hollow Microcapsules
Motion Control of Urea-Powered Biocompatible Hollow Microcapsules
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DOI：
10.1021/acsnano.5b08067
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发表时间：
2016-03-01
期刊：
影响因子：
17.1
通讯作者：
Sanchez, Samuel
中科院分区：
文献类型：
--
作者：
Ma, Xing;Wang, Xu;Sanchez, Samuel
寻求生物相容性的微型游泳者，由兼容的燃料提供动力，并对其自我推进进行完全的运动控制，是活性物质和微型机器人领域的一个长期挑战。在这里，我们提出了一个积极的混合微胶囊电机的基础上Janus中空介孔二氧化硅微粒的生物催化分解尿素在生理浓度供电。定向自推进运动持续时间超过10分钟，平均速度高达每秒S个体长。此外，我们通过化学抑制和重新激活尿素酶的酶活性来控制微电机的速度。在Janus结构内结合磁性材料提供了对运动方向的远程磁性控制。此外，介孔/中空结构可以负载小分子和高达数百纳米的较大颗粒，使混合微马达成为主动和可控的药物递送微系统。
The quest for biocompatible microswimmers powered by compatible fuel and with full motion control over their self propulsion is a long-standing challenge in the field of active matter and microrobotics. Here, we present an active hybrid microcapsule motor based on Janus hollow mesoporous silica microparticles powered by the biocatalytic decomposition of urea at physiological concentrations. The directional self-propelled motion lasts longer than 10 min with an average velocity of up to S body lengths per second. Additionally, we control the velocity of the micromotor by chemically inhibiting and reactivating the enzymatic activity of urease. The incorporation of magnetic material within the Janus structure provides remote magnetic control on the movement direction. Furthermore, the mesoporous/hollow structure can load both small molecules and larger particles up to hundreds of nanometers, making the hybrid micromotor an active and controllable drug delivery microsystem.