Hypoleptinemia in patients with anorexia nervosa: loss of circadian rhythm and unresponsiveness to short-term refeeding
Hypoleptinemia in patients with anorexia nervosa: loss of circadian rhythm and unresponsiveness to short-term refeeding
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DOI：
10.1530/eje.0.1380415
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发表时间：
1998-04-01
影响因子：
5.8
通讯作者：
Lambert, M
中科院分区：
文献类型：
--
作者：
Balligand, JL;Brichard, SM;Lambert, M
瘦素是由ob基因编码的蛋白质，在脂肪细胞中表达并通过神经内分泌机制调节进食行为。在正常、肥胖和肥胖受试者中，血浆瘦素水平已显示与体重和体脂相关。在最后这些人群中，血浆瘦素水平在短期再喂养期间的动态概况从未被评估。因此，我们研究了29名神经性厌食症（AN）女性患者（年龄21.9 ± 1.4岁，体重指数（BMI）15.2 ± 0.3 kg/m2）和80名正常女性对照组（年龄21.2 ± 0.2岁，BMI 20.3 ± 0.3 kg/m2，平均值± S.E.M.）的基础血浆瘦素水平。与对照组相比，AN患者的基础血浆瘦素水平降低了77%（2.5 +/- 0.2 vs 11.1 +/- 0.7 ng/ml，P
Leptin is a protein encoded by the ob gene that is expressed in adipocytes and regulates eating behavior via neuroendocrine mechanisms. Plasma leptin levels have been shown to correlate with weight and body fat in normal, obese and anorexic subjects. In the last of these populations, the dynamic profile of plasma leptin levels during short-term refeeding has never been assessed. We thus investigated basal plasma leptin levels in 29 female patients with anorexia nervosa (AN) (age 21.9 +/- 1.4 years, body mass index (BMI) 15.2 +/- 0.3 kg/m(2)) and in 80 normal female controls (age 21.2 +/- 0.2 years, BMI 20.3 +/- 0.3 kg/m(2), mean +/- S.E.M.). Basal plasma leptin levels in AN were decreased by 77% compared with controls (2.5 +/- 0.2 vs 11.1 +/- 0.7 ng/ml, P