Mortality attributable to hospital acquired infections with multidrug-resistant bacteria in a large group of German hospitals
Mortality attributable to hospital acquired infections with multidrug-resistant bacteria in a large group of German hospitals
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DOI：
10.1016/j.jiph.2019.07.025
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发表时间：
2020-02-01
影响因子：
6.7
通讯作者：
Nachtigall, Irit
中科院分区：
文献类型：
--
作者：
Neubeiser, Alicia;Bonsignore, Marzia;Nachtigall, Irit
背景根据外推，德国每年约有3.5万名患者因耐多药菌(MDRO)而发生医院获得性感染(HAI)，其中约1500人死亡。之前的估计是基于实验室数据和流行率研究。本研究的目的是通过专家复习建立医院获得性耐多药耐药菌感染及其死亡的发生率。方法收集32家医院各级医院获得性多药耐药菌感染的资料。对2016年死亡的MDRO感染患者的死亡记录进行了两位专家的现场复核，以确定感染对死因的影响。结果参与研究的32家医院共治疗了714,108名住院患者。在这些患者中，有1136人发生医院获得性MDRO感染(每1000名患者中有1.59人感染)。2 15例耐多药耐药菌感染者死亡[0.301/1000，(95%可信区间0，2 610,341)]，但仅有78例被估计为死亡原因[0.109/1000病人(95%可信区间0.0 850.133)]。我们审查者调查的这些结果证实了早先的推断。(C)2019年作者。由爱思唯尔有限公司代表沙特国王本·阿卜杜勒阿齐兹健康科学大学出版。这是一篇CC BY-NC-ND许可下的开放获取文章(http：//creativeommons.org/les/by-NC-nd/4.0/)。
Background According to extrapolations, around 35,000 patients in Germany develop hospital acquired infections (HAI) with a multidrug-resistant organism (MDRO) every year, and about 1500 of them die. Previous estimations were based on laboratory data and prevalence studies. Aim of this study was to establish the incidences of hospital acquired MDRO infections and the resulting deaths by expert review.Methods Data on patients suffering from a hospital acquired MDRO infection were collected from 32 hospitals from all care levels. Records of patients with MDRO infection who died in the year 2016 underwent an onsite review by two experts to determine the impact of the infection, if any, on the cause of death.Results A total of 714,108 in-patients were treated in 32 hospitals participating in the study. Of these patients, 1136 suffered a hospital acquired MDRO infection (1.59 per 1000 patients). 215 patients with an MDRO infection died [0.301 per 1000, (95% CI 0,2610,341)], but only in 78 cases this was estimated as the cause of death [0.109 per 1000 patients (95% CI 0.0850.133)].Conclusion By putting the above rates in relation to the total number of in-patients in Germany, it can be rated that around 31,052 patients per year suffer a hospital acquired MDRO infection, and 2132 patients die from it. These results from our reviewer investigation confirm earlier extrapolations.(c) 2019 The Authors. Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz Universityfor Health Sciences. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).