Quantification of pain-induced changes in cerebral blood flow by perfusion MRI
Quantification of pain-induced changes in cerebral blood flow by perfusion MRI
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DOI：
10.1016/j.pain.2007.06.021
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发表时间：
2008-05-01
期刊：
影响因子：
7.4
通讯作者：
Lawrence, K. S. St.
中科院分区：
文献类型：
--
作者：
Owen, D. G.;Bureau, Y.;Lawrence, K. S. St.
本研究的目的是评估疼痛刺激引起的功能激活是否可以用动脉自旋标记（ASL）检测，这是一种用于测量脑血流量（CBF）的无创磁共振成像（MRI）技术，因为ASL直接测量血流量，所以非常适合目前功能性MRI难以评估的疼痛状况，如慢性疼痛。然而，ASL在神经影像学中的使用受到其低灵敏度的阻碍。MRI技术的最新改进，即增加磁场强度和相控阵接收器线圈，应使ASL能够测量与疼痛相关的CBF的微小变化。在这项研究中，健康志愿者接受了两次ASL成像，在此期间，对左手施加疼痛的热刺激。结果表明，ASL技术测量了先前已确定具有疼痛感知的脑区域中局部CBF的变化。这些包括双侧脑血流的变化，在小脑，次级躯体感觉，扣带皮层，以及辅助运动区（SMA）。还观察到对侧初级躯体感觉和同侧丘脑CBF的变化。所有感兴趣区域的CBF平均变化为3.68 ml/100 g/min，范围从同侧丘脑的2.97 ml/100 g/min到对侧丘脑的4.91 ml/100 g/min。平均静息全局CBF为54 +/- 9.7 ml/100 g/min，并且由于有害热刺激，全局CBF没有变化。(c)2007年国际疼痛研究协会。Elsevier B. V.出版，保留所有权利。
The purpose of this study was to assess if the functional activation caused by painful stimuli could be detected with arterial spin labeling (ASL), which is a non-invasive magnetic resonance imaging (MRI) technique for measuring cerebral blood flow (CBF), Because ASL directly measures blood flow, it is well suited to pain conditions that are difficult to assess with current functional MRI, such as chronic pain. However, the use of ASL in neuroimaging has been hampered by its low sensitivity. Recent improvements in MRI technology, namely increased magnetic field strengths and phased array receiver coils, should enable ASL to measure the small changes in CBF associated with pain. In this study, healthy volunteers underwent two ASL imaging sessions, during which a painful thermal stimulus was applied to the left hand. The results demonstrated that the ASL technique measured changes in regional CBF in brain regions that have been previously identified with pain perception. These included bilateral CBF changes in the insula, secondary somatosensory, and cingulate cortices, as well as the supplementary motor area (SMA). Also observed were contralateral primary somatosensory and ipsilateral thalamic CBF changes. The average change in CBF for all regions of interest was 3.68 ml/100 g/min, ranging from 2.97 ml/100 g/min in ipsilateral thalamus to 4.91 ml/100 g/min in contralateral insula. The average resting global CBF was 54 +/- 9.7 ml/100 g/min, and there was no change in global CBF due to the noxious thermal stimulus. (c) 2007 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.