CELLS TRANSMIT SPATIAL INFORMATION BY ORIENTING COLLAGEN-FIBERS
CELLS TRANSMIT SPATIAL INFORMATION BY ORIENTING COLLAGEN-FIBERS
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DOI：
10.1016/s0934-8832(11)80014-4
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发表时间：
1990-01-01
期刊：
影响因子：
--
通讯作者：
MILAM, S
中科院分区：
文献类型：
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作者：
KLEBE, RJ;CALDWELL, H;MILAM, S
当且仅当凝胶被限制在两个或多个边缘时，当细胞在薄胶原膜上培养时，会发生大细胞群的平行取向。细胞体的方向是由凝胶的几何形状决定的。可以证明，细胞对胶原凝胶施加的张力导致胶原纤维在胶原凝胶初始几何形状决定的方向上重新定向。因此，细胞产生的张力导致胶原纤维取向，进而决定细胞的空间取向和形态。因此，在没有细胞间接触的情况下，细胞可以通过向细胞外基质中的胶原纤维施加张力来相互交流。有关环境形状的信息可以通过这种远程力传递。
Parallel orientation of large cell populations occurs when cells are cultured on thin collagen films if and only if a gel is restrained at two or more edges. The direction in which cell bodies orient is determined by the geometry of the gel. It can be shown that tension exerted by cells on a collagen gel leads to reorientation of collagen fibers in a direction determined by the initial geometry of the collagen gel. Hence, tension generated by cells leads to collagen fiber orientation which, in turn, determines the spatial orientation and morphology of cells. Thus, without cell-to-cell contact, cells can communicate with each other by applying tension to collagen fibers in their extracellular matrix. Information concerning the shape of the environment can be transmitted via such long range forces.